Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Sci Rep. 2017 Mar 22;7:45042. doi: 10.1038/srep45042.
The aim of this study was to investigate the correlation between elastography and histologic characteristics including fibrosis and calcification. We also wanted to investigate whether other clinicopathologic indexes influence the strain ratio (SR) of papillary thyroid carcinomas (PTCs). We retrospectively reviewed 126 papillary thyroid carcinomas (PTCs) from 103 patients who underwent ultrasonography and elastography before surgery. The histologic characteristics and clinicopathologic indexes were compared with the SR of ultrasound elastography (UE). The results showed that there was a significantly positive correlation between fibrosis degree and SR measurements (r = 0.754, p = 0.000); the SR was significantly different between the groups with and without calcification (11.34 ± 10.08 vs. 6.81 ± 7.33, p = 0.000). The standard coefficients of collagen and stromal calcification were 0.684 and 0.194, respectively. There was no significant correlation between SR and indices such as size, position, co-existence with Hashimoto's thyroiditis (HT), multifocality or cervical lymph node (CLN) metastasis. In conclusion, we found that the SR of UE is positively correlated with the fibrosis of PTC. Stromal calcification will elevate the SR dramatically, but psammoma bodies will not when they exist in the absence of stromal calcification.
本研究旨在探讨包括纤维化和钙化在内的组织学特征与弹性成像之间的相关性。我们还想研究其他临床病理指标是否会影响甲状腺乳头状癌（PTC）的应变比（SR）。我们回顾性分析了 103 例在术前接受超声和弹性成像检查的患者的 126 例甲状腺乳头状癌（PTC）。将组织学特征和临床病理指标与超声弹性成像（UE）的 SR 进行比较。结果表明，纤维化程度与 SR 测量值之间存在显著正相关（r=0.754，p=0.000）；有钙化和无钙化组之间的 SR 差异有统计学意义（11.34±10.08 比 6.81±7.33，p=0.000）。胶原和间质钙化的标准系数分别为 0.684 和 0.194。SR 与大小、位置、与桥本甲状腺炎（HT）共存、多灶性或颈部淋巴结（CLN）转移等指数之间无显著相关性。总之，我们发现 UE 的 SR 与 PTC 的纤维化呈正相关。间质钙化会显著提高 SR，但当不存在间质钙化时，砂粒体不会。
