Guerra-Gomes Isabel Cristina, Gois Bruna Macêdo, Peixoto Rephany Fonseca, Oliveira Camila Alves, Maciel Bruna Leal Lima, Sarmento Maria Izabel Ferreira, Pachá Anna Stella Cysneiros, Araújo Josélio Maria Galvão, Amaral Ian Porto Gurgel, Keesen Tatjana Souza Lima
Laboratório de Imunologia das Doenças Infecciosas, Departamento de Biologia Celular e Molecular, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
Programa de Pós-Graduação em Biotecnologia, Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
Rev Soc Bras Med Trop. 2017 Jan-Feb;50(1):19-26. doi: 10.1590/0037-8682-0419-2016.
: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil.
: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department. Reverse transcription polymerase chain reaction (RT-PCR) assays for dengue serotypes were carried out on plasma samples obtained from patients with suspected dengue. The data were analysed using descriptive statistics.
: According to clinical features, dengue fever [n = 39,083 (70.2%)] and dengue without warning signs [n = 15,365 (27.7%)] were the most common classifications of dengue. On RT-PCR, DENV 1 was the most commonly identified serotype (80.5%) in all years studied. Co-circulation of all four DENV serotypes was observed in 2013 and 2014. Furthermore, we observed an increase in dengue notifications in 2015, possibly due to the rise of Zika and chikungunya.
: Our findings support the hypothesis that co-circulation of the four DENV serotypes may be a reason for the increased prevalence of severe forms of dengue in the years studied. This study may contribute to directing research, health policy, and financial resources toward reducing poorly controlled epidemic diseases.
尽管登革热是全球最普遍的虫媒病毒病，但最近却受到了忽视。然而，最近寨卡病毒和基孔肯雅热等虫媒病毒在世界各地的流行，已使卫生当局对这些疾病提高了警惕。本研究评估了2007年至2015年巴西东北部帕拉伊巴州登革热的发病模式、临床特征以及血清型的共同流行情况。
2007年至2015年登革热病例的数据，是从帕拉伊巴州卫生部提供的巴西国家法定传染病监测系统[Sistema Nacional de Agravos de Notificação (SINAN)]的临床报告中提取的。对疑似登革热患者的血浆样本进行登革热血清型的逆转录聚合酶链反应（RT-PCR）检测。使用描述性统计方法对数据进行分析。
根据临床特征，登革热热型[n = 39,083例（70.2%）]和无警示体征的登革热[n = 15,365例（27.7%）]是登革热最常见的分类。在RT-PCR检测中，DENV 1是所有研究年份中最常鉴定出的血清型（80.5%）。2013年和2014年观察到所有四种DENV血清型共同流行。此外，我们观察到2015年登革热报告病例增加，这可能是由于寨卡病毒和基孔肯雅热的流行。
我们的研究结果支持这样一种假设，即在研究年份中，四种DENV血清型的共同流行可能是严重登革热形式患病率增加的一个原因。本研究可能有助于将研究、卫生政策和财政资源导向减少控制不佳的流行病。
