Guo Ming, Qu Hua, Xu Lin, Shi Da-Zhuo
China Academy of Chinese Medical Sciences, Beijing, China; Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Nutr Res. 2017 Jun;42:1-10. doi: 10.1016/j.nutres.2017.02.010. Epub 2017 Mar 2.
Several epidemiological investigations have evaluated the correlation between tea consumption and risk of osteoporosis, but the results are inconsistent. Therefore, we conducted an updated meta-analysis of observational studies to assess this association. We searched for all relevant studies including cohort, cross-sectional, and case-control studies published from database inception to July 15, 2016, using MEDLINE EMBASE, and Cochrane Library. Polled odds ratios (ORs) were calculated using the random-effect model. Fourteen articles (16 studies) that examined 138523 patients were included in this meta-analysis. Seven studies concerning bone mineral density (BMD) showed an increase in BMD with tea consumption, including 4 cross-sectional studies (OR, 0.04, 95% confidence interval [CI], 0.01-0.08) and 3 cohort studies (OR, 0.01; 95% CI, 0.01-0.01). The remaining 9 studies concerning fracture, including 6 case-control studies and 3 cohort studies, showed no association between tea consumption and osteoporotic fracture (OR, 0.86; 95% CI, 0.74-1.01). This updated meta-analysis demonstrates that tea consumption could increase BMD, but the association with osteoporotic fracture requires further investigation. Together, the results highlight the need for future, high-quality-designed clinical trials on tea consumption and osteoporosis.
多项流行病学调查评估了饮茶与骨质疏松症风险之间的相关性，但结果并不一致。因此，我们对观察性研究进行了一项更新的荟萃分析，以评估这种关联。我们使用MEDLINE、EMBASE和Cochrane图书馆，检索了从数据库建立到2016年7月15日发表的所有相关研究，包括队列研究、横断面研究和病例对照研究。采用随机效应模型计算合并优势比（OR）。本荟萃分析纳入了14篇文章（16项研究），共涉及138523例患者。7项关于骨密度（BMD）的研究表明，饮茶可使骨密度增加，其中包括4项横断面研究（OR，0.04；95%置信区间[CI]，0.01 - 0.08）和3项队列研究（OR，0.01；95% CI，0.01 - 0.01）。其余9项关于骨折的研究，包括6项病例对照研究和3项队列研究，表明饮茶与骨质疏松性骨折之间无关联（OR，0.86；95% CI，0.74 - 1.01）。这项更新的荟萃分析表明，饮茶可能会增加骨密度，但与骨质疏松性骨折的关联需要进一步研究。总之，结果凸显了未来需要开展高质量设计的关于饮茶与骨质疏松症的临床试验。
