• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗2,4-D转基因作物中有毒代谢物的产生。

Production of a toxic metabolite in 2,4-D-resistant GM crop plants.

作者信息

Lurquin Paul F

机构信息

School of Molecular Biosciences, Washington State University, Pullman, WA, 99164, USA.

, c/o PO Box 369, Cannon Beach, OR, 97110, USA.

出版信息

3 Biotech. 2016 Jun;6(1):82. doi: 10.1007/s13205-016-0387-9. Epub 2016 Feb 23.

DOI:10.1007/s13205-016-0387-9
PMID:28330152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4764611/
Abstract

This Note questions the safety of crop plants engineered with transgenes coding for the degradation of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) into its cytotoxic metabolite 2,4-dichlorophenol (2,4-DCP).

摘要

本注释对通过转基因工程改造的作物安全性提出质疑，这些转基因编码将除草剂2,4-二氯苯氧基乙酸（2,4-D）降解为其细胞毒性代谢物2,4-二氯苯酚（2,4-DCP）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f87/4764611/d5d7536c090a/13205_2016_387_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f87/4764611/d5d7536c090a/13205_2016_387_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f87/4764611/d5d7536c090a/13205_2016_387_Fig1_HTML.jpg

相似文献

1
Production of a toxic metabolite in 2,4-D-resistant GM crop plants.抗2,4-D转基因作物中有毒代谢物的产生。
3 Biotech. 2016 Jun;6(1):82. doi: 10.1007/s13205-016-0387-9. Epub 2016 Feb 23.
2
Combined Toxicity of 2,4-Dichlorophenoxyacetic Acid and Its Metabolites 2,4-Dichlorophenol (2,4-DCP) on Two Nontarget Organisms.2,4-二氯苯氧乙酸及其代谢产物2,4-二氯苯酚（2,4-DCP）对两种非靶标生物的联合毒性
ACS Omega. 2019 Jan 18;4(1):1669-1677. doi: 10.1021/acsomega.8b02282. eCollection 2019 Jan 31.
3
2,4-Dichlorophenoxyacetic acid metabolism in transgenic tolerant cotton (Gossypium hirsutum).转基因耐2,4-二氯苯氧乙酸棉花（陆地棉）中2,4-二氯苯氧乙酸的代谢
J Agric Food Chem. 2000 Nov;48(11):5307-11. doi: 10.1021/jf990672c.
4
Effects of 2,4-D and its metabolite 2,4-dichlorophenol on antioxidant enzymes and level of glutathione in human erythrocytes.2,4-二氯苯氧乙酸及其代谢物2,4-二氯苯酚对人红细胞抗氧化酶及谷胱甘肽水平的影响。
Comp Biochem Physiol C Toxicol Pharmacol. 2003 Aug;135(4):435-41. doi: 10.1016/s1532-0456(03)00151-0.
5
Fungal bioconversion of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4-dichlorophenol (2,4-DCP).2,4-二氯苯氧乙酸（2,4-D）和2,4-二氯苯酚（2,4-DCP）的真菌生物转化
Chemosphere. 2005 Sep;60(10):1471-80. doi: 10.1016/j.chemosphere.2004.11.102.
6
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.转基因植物及其衍生食品和饲料的安全性与营养评估：动物饲养试验的作用
Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13.
7
Toxicity of chlorinated phenoxyacetic acid herbicides in the experimental eukaryotic model Saccharomyces cerevisiae: role of pH and of growth phase and size of the yeast cell population.氯苯氧基乙酸除草剂在实验性真核模型酿酒酵母中的毒性：pH值、酵母细胞群体生长阶段及大小的作用
Chemosphere. 2003 Apr;51(1):47-54. doi: 10.1016/s0045-6535(02)00614-8.
8
Rapid Biodegradation of the Herbicide 2,4-Dichlorophenoxyacetic Acid by Cupriavidus gilardii T-1.铜绿假单胞菌 T-1 快速降解除草剂 2,4-二氯苯氧乙酸。
J Agric Food Chem. 2017 May 10;65(18):3711-3720. doi: 10.1021/acs.jafc.7b00544. Epub 2017 May 1.
9
Expression of a bacterial gene in transgenic tobacco plants confers resistance to the herbicide 2,4-dichlorophenoxyacetic acid.细菌基因在转基因烟草植株中的表达赋予了对除草剂2,4-二氯苯氧乙酸的抗性。
Plant Mol Biol. 1989 Nov;13(5):533-40. doi: 10.1007/BF00027313.
10
Elimination and detoxification of 2,4-D by Umbelopsis isabellina with the involvement of cytochrome P450.伞菌属对 2,4-D 的消除和解毒作用涉及细胞色素 P450。
Environ Sci Pollut Res Int. 2018 Jan;25(3):2738-2743. doi: 10.1007/s11356-017-0571-4. Epub 2017 Nov 14.

本文引用的文献

1
2,4-Dichlorophenoxyacetic acid and non-Hodgkin's lymphoma, gastric cancer, and prostate cancer: meta-analyses of the published literature.2,4-二氯苯氧乙酸与非霍奇金淋巴瘤、胃癌和前列腺癌：已发表文献的荟萃分析。
Ann Epidemiol. 2015 Aug;25(8):626-636.e4. doi: 10.1016/j.annepidem.2015.04.002. Epub 2015 May 6.
2
2,4-Dichlorophenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus.2,4-二氯苯酚通过增加金鱼肝脏中S-腺苷甲硫氨酸以及上调DNA甲基转移酶（DNMTs）mRNA的表达来诱导全基因组DNA高甲基化。
Comp Biochem Physiol C Toxicol Pharmacol. 2014 Mar;160:54-9. doi: 10.1016/j.cbpc.2013.11.008. Epub 2013 Dec 4.
3
Engineering 2,4-D resistance into cotton.
将 2,4-D 抗性导入棉花。
Theor Appl Genet. 1992 Mar;83(5):645-9. doi: 10.1007/BF00226910.
4
2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway.2,4-二氯苯酚通过线粒体途径诱导草鱼（Ctenopharyngodon idella）原代肝细胞凋亡。
Aquat Toxicol. 2013 Sep 15;140-141:117-22. doi: 10.1016/j.aquatox.2013.05.015. Epub 2013 May 28.
5
Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol.2,4-二氯苯酚对体外 H295R 细胞和斑马鱼体内试验中内分泌功能的干扰作用。
Aquat Toxicol. 2012 Jan 15;106-107:173-81. doi: 10.1016/j.aquatox.2011.11.006. Epub 2011 Nov 25.
6
Robust crop resistance to broadleaf and grass herbicides provided by aryloxyalkanoate dioxygenase transgenes.通过芳基烷酸双加氧酶转基因提供对阔叶草和禾本科杂草的抗药性。
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20240-5. doi: 10.1073/pnas.1013154107. Epub 2010 Nov 8.
7
Metabolic fate of [(14)C]-2,4-dichlorophenol in tobacco cell suspension cultures.[(14)C]-2,4-二氯苯酚在烟草细胞悬浮培养物中的代谢命运。
Environ Toxicol Chem. 2007 Nov;26(11):2299-307. doi: 10.1897/07-036R.1.
8
The key role of chlorocatechol 1,2-dioxygenase in phytoremoval and degradation of catechol by transgenic Arabidopsis.氯儿茶酚1,2 - 双加氧酶在转基因拟南芥对儿茶酚的植物修复和降解中的关键作用。
Plant Physiol. 2006 Oct;142(2):620-8. doi: 10.1104/pp.106.085936. Epub 2006 Aug 25.
9
A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats.大鼠2,4-二氯苯酚的两代生殖毒性研究
J Toxicol Sci. 2005 Dec;30 Spec No.:59-78. doi: 10.2131/jts.30.s59.
10
Effects of 2,4-D and DCP on the DHT-induced androgenic action in human prostate cancer cells.2,4-二氯苯氧乙酸和二氯酚对双氢睾酮诱导的人前列腺癌细胞雄激素作用的影响。
Toxicol Sci. 2005 Nov;88(1):52-9. doi: 10.1093/toxsci/kfi287. Epub 2005 Aug 17.