Feng Q, Fang W, Sun X P, Sun S H, Zhang R M, Ma Z J
Department of Radiology, Yidu Central Hospital, Weifang Medical University, No. 4138, Linglongshansouth Road, Qingzhou City, Shandong Province, China.
Department of Radiology, Yidu Central Hospital, Weifang Medical University, No. 4138, Linglongshansouth Road, Qingzhou City, Shandong Province, China.
Clin Radiol. 2017 Jul;72(7):560-564. doi: 10.1016/j.crad.2017.02.016. Epub 2017 Mar 19.
To investigate whether diffusion tensor imaging (DTI) can be used to assess renal clinical histopathology, including the nuclear grade (NG), cell density (CD), and the presence of ki-67.
Thirty patients were enrolled in the study and were confirmed at surgical histopathology to have clear cell renal cell carcinoma (CCRCC). For DTI, a coronal echo-planar imaging sequence was performed (1400 ms repetition time, 76 ms echo time, diffusion direction=6, number of excitations=4; b=0 and 800 s/mm, 6 mm section thickness with no intersection gap). CD and the presence of ki-67 were compared between the different NGs. Correlations between apparent diffusion coefficients (ADCs), E1, fractional anisotropy (FA), CD, and ki-67 were evaluated.
ADC, E1, and FA values are important tools used to identify NG. The cut-off values were 1.003×10 mm/s, 1.277×10 mm/s, and 0.218 mm/s, respectively. The difference between high- and low-grade CD was significant (t=-4.50, p<0.05). Similarly, a significant difference between high and low grade was also found in ki-67 (t=-4.03, p<0.05). ADC, E1, and FA values were decreased with increased CD; a significant negative correlation was found (r=-0.796, -0.865, and -0.996, respectively). Significant negative correlations between ADC, E1, and FA values, and ki-67 were found (r=-0.739, -0.826, and -0.876, respectively).
DTI can be used to non-invasively assess CCRCC.
探讨扩散张量成像（DTI）是否可用于评估肾临床组织病理学，包括核分级（NG）、细胞密度（CD）和ki-67的表达情况。
30例患者纳入本研究，经手术组织病理学确诊为透明细胞肾细胞癌（CCRCC）。对于DTI，采用冠状面回波平面成像序列（重复时间1400 ms，回波时间76 ms，扩散方向=6，激励次数=4；b=0和800 s/mm²，层厚6 mm，无层间间隙）。比较不同NG组之间的CD和ki-67的表达情况。评估表观扩散系数（ADC）、E1、分数各向异性（FA）、CD和ki-67之间的相关性。
ADC、E1和FA值是识别NG的重要工具。截断值分别为1.003×10⁻³mm²/s、1.277×10⁻³mm²/s和0.218。高、低级别CD之间的差异具有统计学意义（t=-4.50，p<0.05）。同样，高、低级别ki-67之间也存在显著差异（t=-4.03，p<0.05）。ADC、E1和FA值随CD增加而降低；发现显著负相关（r分别为-0.796、-0.865和-0.996）。ADC、E1和FA值与ki-67之间存在显著负相关（r分别为-0.739、-0.826和-0.876）。
DTI可用于无创评估CCRCC。
