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Manipulating MicroRNAs in Murine Models: Targeting the Multi-Targeting in Epilepsy.在小鼠模型中操控微小RNA：针对癫痫中的多靶点作用
Epilepsy Curr. 2017 Jan-Feb;17(1):43-47. doi: 10.5698/1535-7511-17.1.43.
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Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy.在多种小鼠和大鼠癫痫模型中，靶向miR-134的锁核酸反义寡核苷酸具有强大的抗癫痫作用。
Mol Ther Nucleic Acids. 2017 Mar 17;6:45-56. doi: 10.1016/j.omtn.2016.11.002. Epub 2016 Dec 10.
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microRNAs in the pathophysiology of epilepsy.微小RNA在癫痫病理生理学中的作用
Neurosci Lett. 2018 Feb 22;667:47-52. doi: 10.1016/j.neulet.2017.01.017. Epub 2017 Jan 16.
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Antagonizing Increased Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.拮抗实验性颞叶癫痫慢性期的升高水平可减少自发性复发癫痫。
J Neurosci. 2019 Jun 26;39(26):5064-5079. doi: 10.1523/JNEUROSCI.3014-18.2019. Epub 2019 Apr 23.
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Epilepsy and microRNA.癫痫与 microRNA。
Neuroscience. 2013 May 15;238:218-29. doi: 10.1016/j.neuroscience.2013.02.027. Epub 2013 Feb 26.
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MicroRNAs as biomarkers and treatment targets in status epilepticus.微小 RNA 作为癫痫持续状态的生物标志物和治疗靶点。
Epilepsy Behav. 2019 Dec;101(Pt B):106272. doi: 10.1016/j.yebeh.2019.04.025. Epub 2019 Jun 4.
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MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model of temporal lobe epilepsy.微小 RNA-23a 促进颞叶癫痫实验模型中海马神经元损伤和空间记忆障碍。
Brain Res Bull. 2019 Oct;152:175-183. doi: 10.1016/j.brainresbull.2019.07.021. Epub 2019 Jul 20.
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The lncRNA H19 binding to let-7b promotes hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy.长链非编码 RNA H19 通过靶向 Stat3 促进颞叶癫痫大鼠模型中海马神经胶质细胞的激活和癫痫发作。
Cell Prolif. 2020 Aug;53(8):e12856. doi: 10.1111/cpr.12856. Epub 2020 Jul 10.
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Involvement of microRNAs in epileptogenesis.微小RNA在癫痫发生中的作用。
Epilepsia. 2016 Jul;57(7):1015-26. doi: 10.1111/epi.13404. Epub 2016 May 21.
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Fever, febrile seizures and epilepsy.发热、热性惊厥和癫痫。
Trends Neurosci. 2007 Oct;30(10):490-6. doi: 10.1016/j.tins.2007.07.006. Epub 2007 Sep 25.
引用本文的文献
1
MicroRNAs in mouse and rat models of experimental epilepsy and potential therapeutic targets.实验性癫痫小鼠和大鼠模型中的微小RNA及潜在治疗靶点。
Neural Regen Res. 2023 Oct;18(10):2108-2118. doi: 10.4103/1673-5374.369093.
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Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap.癫痫发生临床相关生物标志物的鉴定——战略路线图。
Nat Rev Neurol. 2021 Apr;17(4):231-242. doi: 10.1038/s41582-021-00461-4. Epub 2021 Feb 16.
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Prospects and Limitations Related to the Use of MicroRNA as a Biomarker of Epilepsy in Children: A Systematic Review.与使用微小RNA作为儿童癫痫生物标志物相关的前景与局限性：一项系统综述
Life (Basel). 2021 Jan 4;11(1):26. doi: 10.3390/life11010026.
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MicroRNAs in temporal lobe epilepsy: a systematic review.颞叶癫痫中的微小RNA：一项系统综述。
Neurol Sci. 2021 Feb;42(2):571-578. doi: 10.1007/s10072-020-05016-x. Epub 2021 Jan 3.
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MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy.微小RNA作为癫痫患儿炎症的免疫调节因子
Int J Mol Cell Med. 2020 Summer;9(3):188-197. doi: 10.22088/IJMCM.BUMS.9.3.188. Epub 2020 Nov 10.
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A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.系统方法提供了一个功能性 microRNA 目录，并为颞叶癫痫的癫痫抑制扩大了靶标。
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24.
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Dexamethasone Attenuates Hyperexcitability Provoked by Experimental Febrile Status Epilepticus.地塞米松可减轻实验性发热性癫痫持续状态引起的过度兴奋。
eNeuro. 2019 Nov 15;6(6). doi: 10.1523/ENEURO.0430-19.2019. Print 2019 Nov/Dec.
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Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps.血液中微小RNA作为癫痫分子生物标志物的发现与验证：弥补当前知识空白的方法
Epilepsia Open. 2018 Oct 30;3(4):427-436. doi: 10.1002/epi4.12275. eCollection 2018 Dec.
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miR-23a/b promote tumor growth and suppress apoptosis by targeting PDCD4 in gastric cancer.miR-23a/b 通过靶向 PDCD4 促进胃癌的肿瘤生长和抑制细胞凋亡。
Cell Death Dis. 2017 Oct 5;8(10):e3059. doi: 10.1038/cddis.2017.447.
本文引用的文献
1
MicroRNA-132 Interact with p250GAP/Cdc42 Pathway in the Hippocampal Neuronal Culture Model of Acquired Epilepsy and Associated with Epileptogenesis Process.微小RNA-132在获得性癫痫海马神经元培养模型中与p250GAP/Cdc42通路相互作用并与癫痫发生过程相关。
Neural Plast. 2016;2016:5108489. doi: 10.1155/2016/5108489. Epub 2016 Aug 8.
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Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks.抑制微小RNA 128可增强培养的皮质神经元网络的兴奋性。
Genome Res. 2016 Oct;26(10):1411-1416. doi: 10.1101/gr.199828.115. Epub 2016 Aug 11.
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Antagonist Targeting microRNA-155 Protects against Lithium-Pilocarpine-Induced Status Epilepticus in C57BL/6 Mice by Activating Brain-Derived Neurotrophic Factor.靶向微小RNA-155的拮抗剂通过激活脑源性神经营养因子对C57BL/6小鼠锂-匹罗卡品诱导的癫痫持续状态具有保护作用。
Front Pharmacol. 2016 May 31;7:129. doi: 10.3389/fphar.2016.00129. eCollection 2016.
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Protective role of miR-23b-3p in kainic acid-induced seizure.miR-23b-3p在海藻酸诱导的癫痫发作中的保护作用。
Neuroreport. 2016 Jul 6;27(10):764-8. doi: 10.1097/WNR.0000000000000610.
5
Involvement of microRNAs in epileptogenesis.微小RNA在癫痫发生中的作用。
Epilepsia. 2016 Jul;57(7):1015-26. doi: 10.1111/epi.13404. Epub 2016 May 21.
6
Inhibition of miR-203 Reduces Spontaneous Recurrent Seizures in Mice.抑制miR-203可减少小鼠的自发性复发性癫痫发作。
Mol Neurobiol. 2017 Jul;54(5):3300-3308. doi: 10.1007/s12035-016-9901-7. Epub 2016 May 10.
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The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.微小RNA miR-124可抑制癫痫发作活动并调节CREB1活性。
Expert Rev Mol Med. 2016 Mar 21;18:e4. doi: 10.1017/erm.2016.3.
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Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.靶向微小RNA-199a-5p通过SIRT1-p53级联反应预防毛果芸香碱诱导的癫痫持续状态和癫痫损伤。
Epilepsia. 2016 May;57(5):706-16. doi: 10.1111/epi.13348. Epub 2016 Mar 6.
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Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy.沉默miR-181a可对大鼠模型癫痫持续状态后及颞叶癫痫患儿的海马神经元细胞凋亡产生神经保护作用。
Genet Mol Res. 2016 Feb 22;15(1):gmr7798. doi: 10.4238/gmr.15017798.
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microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.微小RNA靶向P2X7嘌呤受体可对抗海马体中的对侧致痫灶。
Sci Rep. 2015 Dec 3;5:17486. doi: 10.1038/srep17486.
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