Dubé Céline M, Brewster Amy L, Richichi Cristina, Zha Qinqin, Baram Tallie Z
Department of Anatomy/Neurobiology, University of California at Irvine, ZOT 4475, Irvine, CA 92697-4475, USA.
Trends Neurosci. 2007 Oct;30(10):490-6. doi: 10.1016/j.tins.2007.07.006. Epub 2007 Sep 25.
Seizures induced by fever (febrile seizures) are the most common type of pathological brain activity in infants and children. These febrile seizures and their potential contribution to the mechanisms of limbic (temporal lobe) epilepsy have been a topic of major clinical and scientific interest. Key questions include the mechanisms by which fever generates seizures, the effects of long febrile seizures on neuronal function and the potential contribution of these seizures to epilepsy. This review builds on recent advances derived from animal models and summarizes our current knowledge of the mechanisms underlying febrile seizures and of changes in neuronal gene expression and function that facilitate the enduring effects of prolonged febrile seizures on neuronal and network excitability. The review also discusses the relevance of these findings to the general mechanisms of epileptogenesis during development and points out gaps in our knowledge, including the relationship of animal models to human febrile seizures and epilepsy.
发热性惊厥是婴幼儿时期最常见的病理性脑活动类型。这些发热性惊厥及其对边缘性（颞叶）癫痫发病机制的潜在影响一直是临床和科研的重点关注话题。关键问题包括发热引发惊厥的机制、长时间发热性惊厥对神经元功能的影响以及这些惊厥对癫痫的潜在作用。本综述基于动物模型的最新进展，总结了我们目前对发热性惊厥潜在机制的认识，以及神经元基因表达和功能变化，这些变化促进了长时间发热性惊厥对神经元和网络兴奋性的持久影响。该综述还讨论了这些发现与发育过程中癫痫发生的一般机制的相关性，并指出了我们知识上的空白，包括动物模型与人类发热性惊厥及癫痫之间的关系。
