氨基葡萄糖和软骨素在犬类骨关节炎中的应用：综述
Glucosamine and chondroitin use in canines for osteoarthritis: A review.
作者信息
Bhathal Angel, Spryszak Meredith, Louizos Christopher, Frankel Grace
机构信息
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
College of Pharmacy, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.
出版信息
Open Vet J. 2017;7(1):36-49. doi: 10.4314/ovj.v7i1.6. Epub 2017 Feb 24.
Abstract
Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine's quality of life, level of comfort, daily functioning, activity, behaviour, and client-pet companionship. Despite limited and conflicting evidence, the natural products glucosamine hydrochloride (HCl) and chondroitin sulfate are commonly recommended by veterinarians for treating osteoarthritis in dogs. There is a paucity of well-designed clinical veterinary studies investigating the true treatment effect of glucosamine and chondroitin. The purposes of this review article are to provide a brief background on glucosamine and chondroitin use in canine osteoarthritis and to critically review the available literature on the role of these products for improving clinical outcomes. Based on critical review, recommendations for practice are suggested and a future study design is proposed.
摘要
骨关节炎是一种缓慢进展且使人衰弱的疾病，影响所有品种的犬类。骨关节炎导致的疼痛和活动能力下降常常对患病犬的生活质量、舒适度、日常功能、活动、行为以及主人与宠物的陪伴关系产生负面影响。尽管证据有限且相互矛盾，但兽医通常会推荐天然产物盐酸氨基葡萄糖和硫酸软骨素用于治疗犬类骨关节炎。目前缺乏精心设计的临床兽医研究来调查氨基葡萄糖和软骨素的真正治疗效果。这篇综述文章的目的是简要介绍氨基葡萄糖和软骨素在犬类骨关节炎治疗中的应用背景，并批判性地回顾关于这些产品改善临床疗效作用的现有文献。基于批判性回顾，提出了实践建议并设计了未来的研究方案。
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