Kim Myunghoo, Kim Chang H
a Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology , Purdue University , West Lafayette , IN , USA.
b Weldon School of Biomedical Engineering, Purdue University , West Lafayette , IN , USA.
Gut Microbes. 2017 Jul 4;8(4):392-399. doi: 10.1080/19490976.2017.1299311. Epub 2017 Feb 28.
The intestinal tract provides ideal niches for several different microbial species, which are collectively called the gut microbiota. A key host immune effector that controls the microbiota and prevents mucosal infection is IgA. Gut microbiota-derived factors are largely classified into molecular pattern recognition receptor ligands and nutrient-derived metabolites including short-chain fatty acids and adenosine triphosphate. Along with host-derived factors such as retinoic acid, various cytokines and cytokine-like molecules, gut microbial products profoundly shape B cell responses. Gut microbial products can directly regulate B cell activation and differentiation. They can also indirectly affect B cells through epithelial cells, T cells, and myeloid cell subsets. We highlight the various direct and indirect mechanisms by which microbial products regulate humoral immunity.
肠道为多种不同的微生物物种提供了理想的生态位，这些微生物统称为肠道微生物群。控制微生物群并预防黏膜感染的关键宿主免疫效应物是免疫球蛋白A（IgA）。肠道微生物衍生的因子主要分为分子模式识别受体配体和营养衍生的代谢产物，包括短链脂肪酸和三磷酸腺苷。与视黄酸、各种细胞因子和细胞因子样分子等宿主衍生因子一起，肠道微生物产物深刻地塑造了B细胞反应。肠道微生物产物可以直接调节B细胞的激活和分化。它们还可以通过上皮细胞、T细胞和髓样细胞亚群间接影响B细胞。我们重点介绍了微生物产物调节体液免疫的各种直接和间接机制。
