Allen A M, Chai S Y, Clevers J, McKinley M J, Paxinos G, Mendelsohn F A
Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australia.
J Comp Neurol. 1988 Mar 8;269(2):249-64. doi: 10.1002/cne.902690209.
Angiotensin II receptor and angiotensin converting enzyme distributions in the human medulla oblongata were localised by quantitative in vitro autoradiography. Angiotensin II receptors were labelled with the antagonist analogue 125I-[Sar1, Ile8] AII while angiotensin converting enzyme was labelled with 125I-351A, a derivative of the specific converting enzyme inhibitor, lisinopril. Angiotensin II receptor binding and angiotensin converting enzyme are present in high concentrations in the nucleus of the solitary tract, the dorsal motor nucleus of vagus, the rostral and caudal ventrolateral reticular nucleus, and in a band connecting the dorsal and ventral regions. In the rostral and caudal ventrolateral reticular nucleus, angiotensin II receptors are distributed in a punctate pattern that registers with neuronal cell bodies. The distribution and density of these cell bodies closely resemble those of catecholamine-containing neurones mapped by others. In view of the known interactions of angiotensin II with both central and peripheral catecholamine-containing neurons of laboratory animals, the current anatomical findings suggest similar interactions between these neuroactive compounds in the human central nervous system. The presence of angiotensin II receptors and angiotensin converting enzyme in the nucleus of the solitary tract, dorsal motor nucleus of vagus, and rostral and caudal ventrolateral reticular nucleus demonstrates sites for central angiotensin II to exert its known actions on vasopressin release and autonomic functions including blood pressure control. These data also suggest a possible interaction between angiotensin II and central catecholeminergic systems.
通过定量体外放射自显影法对人延髓中的血管紧张素II受体和血管紧张素转换酶分布进行了定位。血管紧张素II受体用拮抗剂类似物125I-[Sar1，Ile8]AII标记，而血管紧张素转换酶用125I-351A标记，125I-351A是特异性转换酶抑制剂赖诺普利的衍生物。血管紧张素II受体结合和血管紧张素转换酶在孤束核、迷走神经背运动核、延髓头端和尾端腹外侧网状核以及连接背侧和腹侧区域的一条带中高浓度存在。在延髓头端和尾端腹外侧网状核中，血管紧张素II受体以点状模式分布，与神经元细胞体相对应。这些细胞体的分布和密度与其他人绘制的含儿茶酚胺神经元的分布和密度非常相似。鉴于血管紧张素II与实验动物中枢和外周含儿茶酚胺神经元之间已知的相互作用，目前的解剖学发现表明这些神经活性化合物在人类中枢神经系统中存在类似的相互作用。孤束核、迷走神经背运动核以及延髓头端和尾端腹外侧网状核中存在血管紧张素II受体和血管紧张素转换酶，这表明中枢血管紧张素II可在这些部位对血管加压素释放和包括血压控制在内的自主功能发挥其已知作用。这些数据还表明血管紧张素II与中枢儿茶酚胺能系统之间可能存在相互作用。
