Maeda Takahiro, Tomita Masuomi, Nakazawa Atsushi, Sakai Gen, Funakoshi Shinsuke, Komatsuda Akari, Ito Yujiro, Nagata Hirohiko, Tsukada Nobuhiro, Nakamura So
Department of Urology, Saiseikai Central Hospital, Tokyo, Japan.
Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan.
Biomed Res Int. 2017;2017:2138073. doi: 10.1155/2017/2138073. Epub 2017 Feb 28.
This noninterventional cross-sectional study aims to assess the association between functional constipation (FC) and urinary symptoms in female patients with no treatment for urination and defecation. The Rome III criteria for evaluation of defecation, Overactive Bladder Symptom Score (OABSS) for evaluation of urinary symptoms, and clinical features were investigated in 145 female patients. Latent FC and moderate to severe overactive bladder (OAB) were defined on the basis of positivity for two or more of the Rome III criteria and an OABSS ≥ 6 with OABSS Q3 ≥ 2, respectively. In 60 latent FC patients, the OABSS was higher (5.0 versus 3.2, = 0.001), and concurrent moderate to severe OAB symptoms and OAB with urinary incontinence were more frequent than those in 85 nonlatent FC patients (33.3 versus 10.6%, = 0.001, and 31.7 versus 7.1%, < 0.001). Multivariate analysis demonstrated that moderate to severe OAB symptoms were a significant associated factor of latent FC (odds ratio (OR) = 4.125, = 0.005), while latent FC was the only associated factor of moderate to severe OAB and OAB with urinary incontinence (OR = 4.227, = 0.005 and OR = 4.753, = 0.004). In conclusion, moderate to severe OAB symptoms are correlated with FC. Moreover, FC is related to moderate to severe OAB symptoms and to OAB with urinary incontinence.
这项非干预性横断面研究旨在评估未接受排尿和排便治疗的女性患者中，功能性便秘（FC）与泌尿系统症状之间的关联。对145名女性患者进行了排便评估的罗马III标准、泌尿系统症状评估的膀胱过度活动症症状评分（OABSS）以及临床特征调查。分别根据罗马III标准中两项或更多项呈阳性以及OABSS≥6且OABSS Q3≥2来定义潜在性FC和中度至重度膀胱过度活动症（OAB）。在60名潜在性FC患者中，OABSS更高（5.0对3.2，P = 0.001），同时中度至重度OAB症状以及伴有尿失禁的OAB比85名非潜在性FC患者更常见（33.3%对10.6%，P = 0.001，以及31.7%对7.1%，P < 0.001）。多因素分析表明，中度至重度OAB症状是潜在性FC的一个显著相关因素（优势比（OR）= 4.125，P = 0.005），而潜在性FC是中度至重度OAB以及伴有尿失禁的OAB的唯一相关因素（OR = 4.227，P = 0.005和OR = 4.753，P = 0.004）。总之，中度至重度OAB症状与FC相关。此外，FC与中度至重度OAB症状以及伴有尿失禁的OAB相关。
