Forensic Science South Australia, 21 Divett Place, Adelaide, SA, 5000, Australia.
School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.
Int J Legal Med. 2017 Nov;131(6):1513-1521. doi: 10.1007/s00414-017-1573-y. Epub 2017 Mar 23.
We present here the derivation of paternity index formulae that covers situations of a disputed paternity trio with a trisomic product of conception. We consider six possible mechanisms for trisomy to occur: dispermy, dieggy, paternal meiosis I or II, and maternal meiosis I or II in the calculation. We also provide a biological explanation for how each of the mechanisms could give rise to a trisomy. The paper is set out in a general manner so that the tables presented can be used on any instance of trisomic offspring. This work is motivated by a case of disputed paternity where the product of conception was trisomic, i.e. the electropherogram of the product of conception possessed three alleles at each locus. The outcome was extremely strong support for the alleged father's paternity of the product of conception.
我们在此介绍了亲权指数公式的推导过程，该公式涵盖了存在争议的三联体与三体受孕产物的亲权情况。我们在计算中考虑了六种可能导致三体发生的机制：多精入卵、合子内有丝分裂、父源减数分裂 I 或 II 以及母源减数分裂 I 或 II。我们还为每种机制如何导致三体提供了生物学解释。本文以通用的方式呈现，以便呈现的表格可用于任何三体后代的情况。这项工作的动机是一个有争议的亲权案例，其中受孕产物是三体的，即受孕产物的电泳图谱在每个位点都有三个等位基因。结果是对所谓父亲是受孕产物的亲生父亲的极有力支持。
