与白人女性相比，中东/北非族裔女性的活产率有所下降。
Decreased live births among women of Middle Eastern/North African ethnicity compared to Caucasian women.
作者信息
Salem W H, Abdullah A, Abuzeid O, Bendikson K, Sharara F I, Abuzeid M
机构信息
University of Southern California, 020 Zonal Ave, IRD Room 533, Los Angeles, CA, 90033, USA.
IVF Michigan, Rochester Hills/Flint MI, 3950 S Rochester Rd, Ste 2300, Rochester Hills, MI, 48307, USA.
出版信息
J Assist Reprod Genet. 2017 May;34(5):581-586. doi: 10.1007/s10815-017-0904-8. Epub 2017 Mar 24.
PURPOSE
The objective of this study is to determine if IVF outcome disparities exist among MENA women in the USA in comparison to a control group of Caucasian women.
METHODS
A retrospective cohort study comparing MENA (N = 190) and Caucasian (N = 200) women undergoing their first IVF cycle between 5/2006 and 5/2014 was carried out at an academically affiliated fertility practice. All MENA cycles during that time period undergoing IVF/ICSI using autologous embryos and blastocyst transfers were compared to a control group of Caucasian women.
RESULTS
MENA women were significantly younger (32.9 vs 34.5, P < 0.005) and had a lower BMI (25.2 vs 27.1, P < 0.001). Male factor infertility was higher among partners of MENA women (62 vs 50%, P < 0.05). MENA women experienced decreased live birth rates per blastocyst transfer compared to Caucasian women after controlling for age and BMI (OR 0.55, 95% CI 0.35-0.85 P = 0.007). The odds of a miscarriage were also significantly higher among MENA women (OR 2.55, 95% CI 1.04-6.27 P = 0.036).
CONCLUSION
Middle Eastern/North African women have worse IVF outcomes with decreased live birth rates per blastocyst transfer and increased miscarriage rates compared to Caucasian women.
目的
本研究的目的是确定与白人女性对照组相比，美国中东和北非（MENA）地区的女性在体外受精（IVF）治疗结果上是否存在差异。
方法
在一家学术附属的生育诊所开展了一项回顾性队列研究，比较了2006年5月至2014年5月期间进行首次IVF周期治疗的MENA女性（N = 190）和白人女性（N = 200）。将该时间段内所有使用自体胚胎并进行囊胚移植的MENA IVF周期与白人女性对照组进行比较。
结果
MENA女性明显更年轻（32.9岁对34.5岁，P < 0.005），体重指数（BMI）更低（25.2对27.1，P < 0.001）。MENA女性伴侣的男性因素不孕症发生率更高（62%对50%，P < 0.05）。在控制年龄和BMI后，与白人女性相比，MENA女性每次囊胚移植后的活产率降低（比值比[OR] 0.55，95%置信区间[CI] 0.35 - 0.85，P = 0.007）。MENA女性流产的几率也显著更高（OR 2.55，95% CI 1.04 - 6.27，P = 0.036）。
结论
与白人女性相比，中东/北非女性的IVF治疗结果更差，每次囊胚移植后的活产率降低，流产率增加。
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