Ferro Francesco, Marcucci Elisa, Orlandi Martina, Baldini Chiara, Bartoloni-Bocci Elena
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Rheumatology Unit, University of Perugia, Italy.
Clin Exp Rheumatol. 2017 Mar-Apr;35(2):179-191. Epub 2017 Mar 15.
Primary Sjögren's syndrome (pSS) is a complex and heterogeneous disease. Last year, a great deal of basic and clinical research was carried out in pSS. Following the previous reviews of this publishing series, we will herewith provide a critical digest of the most recent literature on pSS pathogenesis, clinical manifestations and treatment. More specifically, we will focus on the heterogeneity of the disease, on the underlying pathogenetic pathways and on the possible new targeted treatments on the horizon.
原发性干燥综合征（pSS）是一种复杂的异质性疾病。去年，针对pSS开展了大量基础和临床研究。继本出版系列之前的综述之后，我们在此对有关pSS发病机制、临床表现和治疗的最新文献进行批判性总结。更具体地说，我们将关注该疾病的异质性、潜在的发病途径以及即将出现的可能的新靶向治疗方法。
