Liu Baohua
Department of General Surgery, Center of Constipation Diagnosis and Treatment, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Mar 25;20(3):255-257.
The correlation between chronic constipation and colorectal neoplasms has been arousing wide interest. There have been a number of domestic and international epidemiological and clinical researches focusing on this issue. Based on these researches, the correlation between constipation and colorectal neoplasms was studied from three aspects: constipation and colorectal polyps; constipation and colorectal cancer; melanosis coli (MC), laxatives and colorectal neoplasms. We find that constipation can significantly increase the incidence of colorectal polyps and constipation does not significantly increase the incidence of colorectal cancer but is one of the risk factors for colorectal cancer. In addition, MC, laxatives and the incidence of colorectal polyps are also closely correlated. Given the fact that colorectal polyps are precancerous lesions, patients with long-term constipation should take less anthraquinone laxatives, and those with colorectal polyps should be followed up periodically.
慢性便秘与结直肠肿瘤之间的相关性一直备受广泛关注。国内外已有多项流行病学和临床研究聚焦于此问题。基于这些研究,从三个方面对便秘与结直肠肿瘤的相关性进行了研究:便秘与结直肠息肉;便秘与结直肠癌;结肠黑变病(MC)、泻药与结直肠肿瘤。我们发现,便秘可显著增加结直肠息肉的发病率,便秘虽未显著增加结直肠癌的发病率,但却是结直肠癌的危险因素之一。此外,MC、泻药与结直肠息肉的发病率也密切相关。鉴于结直肠息肉是癌前病变,长期便秘患者应少用蒽醌类泻药,患有结直肠息肉的患者应定期随访。