黄连木油减轻大鼠小肠缺血再灌注后的肝损伤：抗氧化和抗炎作用
Liver injury following small intestinal ischemia reperfusion in rats is attenuated by Pistacia lentiscus oil: antioxidant and anti-inflammatory effects.
作者信息
Saidi Saber Abdelkader, Ncir Marwa, Chaaben Rim, Jamoussi Kamel, van Pelt Jos, Elfeki Abdelfattah
机构信息
a Department of Life Sciences , Laboratory of Animal Ecophysiology, University of Sfax , Sfax , Tunisia.
b Department of Hepatology , University Hospitals KU Leuven , Leuven , Belgium.
出版信息
Arch Physiol Biochem. 2017 Oct;123(4):199-205. doi: 10.1080/13813455.2017.1302961. Epub 2017 Mar 24.
CONTEXT
Intestinal ischemia-reperfusion (IIR) not only leads to severe intestine damage but also induced subsequent destruction of remote organs.
OBJECTIVE
We investigated the protective effect of Pistascia lentiscus L. (Anacardiaceae) oil on IIR.
MATERIALS AND METHODS
Wistar rats were divided into three groups: sham, intestinal IR and P. lentiscus pretreatment (n = 18 each). In the pretreatment group, oil was administered 1 h before induction of warm ischemia.
RESULTS
IIR led to severe liver damage manifested as a significant (p < .05) increase of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Pistacia lentiscus oil decreased the visible intestinal damage, as well as a significant decrease in serum AST and ALT levels. In addition, Pistacia lentiscus reduce liver injury, as evidenced by the decrease in liver tissue myeloperoxidase activity and lipoperoxidation (MDA) level.
CONCLUSION
Pistascia lentiscus attenuates liver injury induced by IIR, attributable to the antioxidant and anti-inflammatory effect.
背景
肠道缺血再灌注（IIR）不仅会导致严重的肠道损伤，还会引发后续远处器官的破坏。
目的
我们研究了乳香黄连木油对IIR的保护作用。
材料与方法
将Wistar大鼠分为三组：假手术组、肠道缺血再灌注组和乳香黄连木预处理组（每组n = 18）。在预处理组中，在诱导热缺血前1小时给予油剂。
结果
IIR导致严重的肝损伤，表现为天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平显著（p < 0.05）升高。乳香黄连木油减轻了可见的肠道损伤，同时血清AST和ALT水平也显著降低。此外，乳香黄连木减轻了肝损伤，肝组织髓过氧化物酶活性和脂质过氧化（MDA）水平降低证明了这一点。
结论
乳香黄连木减轻了IIR诱导的肝损伤，这归因于其抗氧化和抗炎作用。
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