ARC Centre of Excellence for Functional Nanomaterials, School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.
Small. 2013 Nov 11;9(21):3554-60. doi: 10.1002/smll.201300761. Epub 2013 Apr 29.
The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver-stimulated cellular oxidative stress, ranging from only minimal cellular redox imbalance to the lethal levels of cellular ROS stimulation. An important implication of the present work is that such adaptive effects lead to the ultimate domination of nanosilver-resistant Bacillus sp. in the microbiota, to which nanosilver cytotoxicity is continuously applied.
首次报道了芽孢杆菌在长期暴露于纳米银的细胞毒性时自然适应的能力。在各种强度的纳米银刺激细胞氧化应激下，诱导了纳米银抗性和增强生长的联合适应性效应，范围从仅轻微的细胞氧化还原失衡到细胞 ROS 刺激的致死水平。本工作的一个重要意义是，这种适应性效应导致了纳米银抗性芽孢杆菌在持续应用纳米银细胞毒性的微生物群中最终占主导地位。
