Morales-Durán Nami, León-Buitimea Angel, Morones-Ramírez José R
Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, 66455, Mexico.
Centro de Investigación en Biotecnología y Nanotecnología, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Parque de Investigación e Innovación Tecnológica, Apodaca, 66628, Mexico.
Heliyon. 2024 Mar 11;10(6):e27984. doi: 10.1016/j.heliyon.2024.e27984. eCollection 2024 Mar 30.
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are the main drivers in developing drug-resistant bacteria. The emergence of the rapid global spread of multi-resistant bacteria requires urgent multisectoral action to generate novel treatment alternatives. Combination therapy offers the potential to exploit synergistic effects for enhanced antibacterial efficacy of drugs. Understanding the complex dynamics and kinetics of drug interactions in combination therapy is crucial. Therefore, this review outlines the current advances in antibiotic resistance's evolutionary and genetic dynamics in combination therapies-exposed bacteria. Moreover, we also discussed four pivotal future research areas to comprehend better the development of antibiotic resistance in bacteria treated with combination strategies.
抗菌药物耐药性是全球健康面临的威胁。抗菌药物的滥用和过度使用是导致耐药菌产生的主要驱动因素。多重耐药菌在全球迅速传播，这一情况的出现需要多部门立即采取行动，以开发新的治疗方案。联合疗法有可能利用协同效应来提高药物的抗菌效果。了解联合疗法中药物相互作用的复杂动态和动力学至关重要。因此，本综述概述了联合治疗暴露细菌中抗生素耐药性的进化和遗传动态方面的当前进展。此外，我们还讨论了四个关键的未来研究领域，以便更好地理解联合策略治疗的细菌中抗生素耐药性的发展。
