麻醉剂和压力对多层二棕榈酰磷脂酰胆碱脂质体热致行为的影响。
Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes.
作者信息
Mountcastle D B, Biltonen R L, Halsey M J
出版信息
Proc Natl Acad Sci U S A. 1978 Oct;75(10):4906-10. doi: 10.1073/pnas.75.10.4906.
Abstract
The effects of gaseous anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoyl-phosphatidylcholine liposomes were studied by using a high-sensitivity differential scanning calorimeter. It was found that halothane and enflurane decreased the transition temperature and increased the width of the transition without affecting the enthalpy change for the main gel-to-liquid crystalline transition. This demonstrated that the anesthetics decreased the degree of cooperative interaction between phospholipid molecules within the bilayer. Increasing the pressure increased the transition temperature but did not affect the transition width or enthalpy change. However, the increase in pressure reversed the effect of anesthetic on both the transition temperature and transition width. It is suggested that an understanding of the effect of anesthetics on the degree of cooperative interaction between phospholipids may be a key to understanding anesthetic action.
摘要
利用高灵敏度差示扫描量热仪研究了气态麻醉剂和压力对多层二棕榈酰磷脂酰胆碱脂质体热致行为的影响。结果发现，氟烷和恩氟烷降低了转变温度，增加了转变宽度，但不影响主要的凝胶态到液晶态转变的焓变。这表明麻醉剂降低了双层内磷脂分子间的协同相互作用程度。增加压力会提高转变温度，但不影响转变宽度或焓变。然而，压力的增加逆转了麻醉剂对转变温度和转变宽度的影响。有人认为，了解麻醉剂对磷脂间协同相互作用程度的影响可能是理解麻醉作用的关键。
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