Krupina Nataliya A, Churyukanov Maxim V, Kukushkin Mikhail L, Yakhno Nikolay N
Laboratory of General Pathology of the Nervous System, The Institute of General Pathology and Pathophysiology, Moscow, Russia.
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Front Neurol. 2020 Jan 21;10:1380. doi: 10.3389/fneur.2019.01380. eCollection 2019.
Pain has a significant impact on the quality of life of patients with multiple sclerosis (MS). However, the neurophysiological mechanisms of central neuropathic pain in a MS course are not known. We hypothesized that changes in power spectral density (PSD) that take place in the electroencephalography (EEG) of MS patients with and without the central neuropathic pain (CNP) would differ. The study aimed to assess the features of quantitative EEG using the PSD indicator along with peak frequencies in the standard frequency bands in MS patients with and without CNP. We have analyzed the quantitative spectral content of the EEG at a resting state in 12 MS patients with CNP, 12 MS patients without CNP, and 12 gender- and age-matched healthy controls using fast Fourier transformation. Based on the ANOVA, at the group level, the theta band absolute and relative PSD showed an increase, whereas alpha band relative PSD showed a decrease in MS patients both with and without CNP. However, only in MS with CNP group, the absolute and relative PSD in the beta1 and beta2 bands increased and exceeded that in patients without pain. Only MS patients with CNP demonstrated the significantly increased absolute PSD for the theta, beta1, and beta2 frequency bands in most regions of interest. In the theta band, MS patients with CNP displayed the increase in absolute spectral power for the mid-temporal derivation of the right hemisphere and the increase in relative spectral power for the prefrontal derivation of this hemisphere. In the beta1 band, the increase in absolute spectral power was observed for the three temporal derivations of the right hemisphere, whereas in the beta2 band, for the occipital, parietal, and temporal lobes of both hemispheres. In the alpha band, only a relative spectral power decrease was revealed for the occipital lobes of both hemispheres and parietal lobe of the right hemisphere. In MS patients with CNP, the frequencies of the dominant spectral power (peak frequencies) in the high-frequency beta band were higher than in the healthy control in posterior areas of the left hemisphere. Data could represent central nervous system alterations related to central neuropathic pain in MS patients that lead to the disturbances in cortical communication.
疼痛对多发性硬化症（MS）患者的生活质量有重大影响。然而，MS病程中中枢神经性疼痛的神经生理机制尚不清楚。我们假设，患有和未患有中枢神经性疼痛（CNP）的MS患者脑电图（EEG）中发生的功率谱密度（PSD）变化会有所不同。该研究旨在使用PSD指标以及标准频段的峰值频率评估有和没有CNP的MS患者定量脑电图的特征。我们使用快速傅里叶变换分析了12例患有CNP的MS患者、12例未患有CNP的MS患者以及12例年龄和性别匹配的健康对照在静息状态下EEG的定量频谱内容。基于方差分析，在组水平上，θ频段的绝对和相对PSD均增加，而α频段的相对PSD在患有和未患有CNP的MS患者中均降低。然而，仅在患有CNP的MS组中，β1和β2频段的绝对和相对PSD增加并超过了无疼痛患者。只有患有CNP的MS患者在大多数感兴趣区域的θ、β1和β2频段显示出绝对PSD显著增加。在θ频段，患有CNP的MS患者右半球颞中导联的绝对频谱功率增加，该半球前额导联的相对频谱功率增加。在β1频段，右半球三个颞导联的绝对频谱功率增加，而在β2频段，两个半球的枕叶、顶叶和颞叶的绝对频谱功率增加。在α频段，仅两个半球枕叶和右半球顶叶的相对频谱功率降低。在患有CNP的MS患者中，左半球后部区域高频β频段的主导频谱功率（峰值频率）高于健康对照。这些数据可能代表与MS患者中枢神经性疼痛相关的中枢神经系统改变，这些改变导致皮质通讯紊乱。
