Folkers K, Choe J Y, Combs A B
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5178-80. doi: 10.1073/pnas.75.10.5178.
The administration of adriamycin to rates increased (P less than 0.01) the interval, measured in msec, of the electrocardiographic QRS traces in rats, and the magnitude of the increase was ca. 50%. The administration of coenzyme Q10 to such adriamycin-treated rats allowed "rescue" or restoration of a normal QRS complex after 7 days of administration of coenzyme Q10. The QRS complex then remained normalized during the subsequent period of 21-30 days, by which time the cumulative dose of adriamycin had reached 24 mg/kg. Also, the QRS interval was lower (P less than 0.01) on day 33 than it was for rats treated to the same day with adriamycin alone. Coenzyme Q10 offers promise of rescue from at least some of the cardiotoxicity occurring in adriamycin-treated cancer patients, probably by a similar mechanism to that of the clinical rescue from toxicity of methotrexate by a cofactor of folic acid (citrovorum factor).
给大鼠注射阿霉素会使大鼠心电图QRS波群间期（以毫秒计）增加（P<0.01），增加幅度约为50%。给接受过阿霉素治疗的大鼠注射辅酶Q10，在注射辅酶Q10 7天后可“挽救”或恢复正常的QRS波群。在随后的21 - 30天内，QRS波群一直保持正常，此时阿霉素的累积剂量已达到24mg/kg。此外，在第33天，QRS间期比同日仅接受阿霉素治疗的大鼠更低（P<0.01）。辅酶Q10有望至少挽救部分接受阿霉素治疗的癌症患者出现的心脏毒性，其机制可能与叶酸的一种辅助因子（甲酰四氢叶酸）临床挽救甲氨蝶呤毒性的机制相似。
