Carter I W, Fraser J R, Cloonan M J
Department of Microbiology, Prince Henry Hospital, Little Bay, NSW.
Immunol Cell Biol. 1987 Dec;65 ( Pt 6):511-3. doi: 10.1038/icb.1987.60.
Sera were collected over a period of several years from the onset of initial symptoms from 77 patients with Ross River virus infection. When tested for virus-specific IgA antibodies, using an enzyme-linked immunosorbent assay (ELISA) based on antibody class capture, 245 out of 704 sera were antibody-positive. Although Ross River virus IgA antibodies were present in the serum of all patients soon after onset of symptoms, the IgA response was relatively short-lived in comparison with specific IgM antibodies. The results suggested that the detection of high levels of Ross River virus IgA antibodies was of potential value in differentiating between recent and past infection, especially in those patients with persisting IgM antibodies.
在数年时间里，从77例罗斯河病毒感染患者出现初始症状开始收集血清。使用基于抗体类别捕获的酶联免疫吸附测定（ELISA）检测病毒特异性IgA抗体时，704份血清中有245份抗体呈阳性。尽管所有患者在症状出现后不久血清中就存在罗斯河病毒IgA抗体，但与特异性IgM抗体相比，IgA反应持续时间相对较短。结果表明，检测高水平的罗斯河病毒IgA抗体在区分近期感染和既往感染方面具有潜在价值，尤其是在那些持续存在IgM抗体的患者中。
