Li Yansheng, Cheng Yaya, Xu Liping, Du Hongwu, Zhang Peixun, Wen Yongqiang, Zhang Xueji
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China.
Peking University People's Hospital, Beijing 100083, China.
Nanomaterials (Basel). 2016 Jan 22;6(2):24. doi: 10.3390/nano6020024.
In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS "hotspots". This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection.
在本文中，通过一种通用方法制备了在DNA连接两端相连的高度纯化且稳定的金纳米颗粒（AuNP）二聚体。基于DNA纳米机器通过控制表面增强拉曼散射（SERS）“热点”的形成/变形来控制金纳米颗粒（AuNP）的组装，构建了一种纳米结构的SERS开关传感器系统。该策略不仅以高度可控和可重复的方式为金-金纳米结构中间隙距离的精确工程开辟了机会，还为研究SERS的起源和序列特异性DNA检测提供了独特的能力。
