Kang Byunghoon, Kukreja Aastha, Song Daesub, Huh Yong-Min, Haam Seungjoo
Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seoul, Korea.
College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, Korea.
J Biol Eng. 2017 Mar 23;11:13. doi: 10.1186/s13036-016-0044-1. eCollection 2017.
Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.
纳米医学领域中，用于肿瘤特异性递送和诊断的刺激响应性可激活纳米探针的研究显著增加。肿瘤微环境具有特定特征，可利用这些特征基于正常组织与肿瘤组织之间的差异来实施治疗策略，这些差异包括pH值、氧合作用、酶表达、基因激活/失活以及脉管系统等方面。可激活纳米颗粒的纳米载体在体内循环时保持其结构，到达肿瘤部位后，会因独特的肿瘤刺激而发生改变，从而导致药物或其他制剂的释放。本综述展示了在利用内部刺激响应性可激活纳米颗粒方面，在独特设计策略和应用方面的最新成果。
