Mitsuyama N, Morimoto T, Kinouchi Y, Iritani T, Sumi T, Kimura S, Monden Y
Second Department of Surgery, School of Medicine, University of Tokushima.
Nihon Geka Gakkai Zasshi. 1988 Feb;89(2):251-5.
The electrical bio-impedance of 17 breast tumors including 12 breast cancers and 5 fibroadenomas, were measured in vivo with three-electrode method in the frequency range of 0 to 200 KHZ. The three-electrode consists of a coaxial needle electrode inserted into the tumor and a large reference electrode on upper abdominal wall. The tissue can be regarded electrically as a equivalent consisted of extracellular resistance (R1), intracellular resistance (R2), and electric capacitance of the cell membrane (C). These three parameters were calculated from the measured values of electrical bioimpedance. It was found that R1, and R2 of breast cancers were significantly higher than those of fibroadenomas (p less than 0.001), and that C of breast cancers was significantly lower than that of fibroadenomas (p less than 0.001). The measurement of the electrical impedance of breast tumor in vivo may be useful for the differential diagnosis of breast lesions.
采用三电极法在0至200千赫兹频率范围内对17个乳腺肿瘤（包括12个乳腺癌和5个纤维腺瘤）的生物电阻抗进行了活体测量。三电极由插入肿瘤的同轴针电极和上腹壁的大参考电极组成。组织在电学上可视为由细胞外电阻（R1）、细胞内电阻（R2）和细胞膜电容（C）组成的等效物。这三个参数由生物电阻抗测量值计算得出。结果发现，乳腺癌的R1和R2显著高于纤维腺瘤（p<0.001），且乳腺癌的C显著低于纤维腺瘤（p<0.001）。活体测量乳腺肿瘤的电阻抗可能有助于乳腺病变的鉴别诊断。
