Morimoto T, Kinouchi Y, Iritani T, Kimura S, Konishi Y, Mitsuyama N, Komaki K, Monden Y
Second Department of Surgery, School of Medicine, University of Tokushima, Japan.
Eur Surg Res. 1990;22(2):86-92. doi: 10.1159/000129087.
A new impedance analytical system was developed, and measurements were performed over a frequency range of 0-200 kHz by the three-electrode method. The three electrodes consist of a coaxial needle electrode inserted into the tumor and a large reference electrode on the upper abdominal wall. The electrical bio-impedance was measured in 54 patients with breast tumors. The biological tissue can be regarded electrically as an equivalent consisting of extracellular resistance (Re), intracellular resistance (Ri), and electrical capacitance of the cell membrane (Cm). These three parameters were calculated from the measured values of electrical bio-impedance by the curve-fitting technique using a computer program. It was found that Re and Ri of breast cancers were significantly higher than those of benign tumors (p less than 0.01), and that Cm of breast cancers was significantly lower than that of benign tumors (p less than 0.01). Measurement of the electrical bio-impedance of breast tumors may have value in the differential diagnosis of breast lesions.
开发了一种新的阻抗分析系统，并采用三电极法在0 - 200 kHz的频率范围内进行测量。三电极包括插入肿瘤的同轴针电极和上腹壁的大参考电极。对54例乳腺肿瘤患者进行了生物电阻抗测量。生物组织在电学上可视为由细胞外电阻（Re）、细胞内电阻（Ri）和细胞膜电容（Cm）组成的等效物。通过使用计算机程序的曲线拟合技术，从生物电阻抗测量值计算出这三个参数。发现乳腺癌的Re和Ri显著高于良性肿瘤（p < 0.01），且乳腺癌的Cm显著低于良性肿瘤（p < 0.01）。乳腺肿瘤生物电阻抗的测量在乳腺病变的鉴别诊断中可能具有价值。
