Morimoto T, Kimura S, Konishi Y, Komaki K, Uyama T, Monden Y, Kinouchi Y, Iritani T
School of Medical Sciences, University of Tokushima, Japan.
J Invest Surg. 1993 Jan-Feb;6(1):25-32. doi: 10.3109/08941939309141189.
A new system of impedance measurement over a frequency range of 0 to 200 kHz was developed by a three-electrode method. In this study, the electrical impedances of various tumors were measured in vivo in 54 patients with breast disease (31 breast cancers, 13 fibroadenomas, and 10 fibrocystic diseases) and 57 patients with pulmonary disease (44 lung cancers, 5 metastatic pulmonary tumors, 4 pulmonary tuberculoses, and 4 organized pneumonias). On the basis of those impedance measurements and the equivalent circuits in vivo, we calculated the extracellular resistance (Re), intracellular fluid resistance (Ri), and cell membrane capacitance (Cm) in tissues, all of which were compared among the various diseases. It was found that Re and Ri were significantly higher in breast cancers than in benign tumors and normal breast tissues and that Cm was significantly lower in breast cancers than in other tissues. On the other hand, Re and Ri were significantly higher, and Cm was significantly lower, in normal lung tissues than in pulmonary masses. Re and Ri were significantly higher, and Cm was significantly lower, in malignant tumors than in organized pneumonias. The results showed that these parameters (Re, Ri, and Cm) exhibit significant differences among various tissues and tumors, suggesting possible applications in tumor diagnosis.
采用三电极法开发了一种新的在0至200 kHz频率范围内进行阻抗测量的系统。在本研究中，对54例乳腺疾病患者（31例乳腺癌、13例纤维腺瘤和10例纤维囊性疾病）和57例肺部疾病患者（44例肺癌、5例肺转移瘤、4例肺结核和4例机化性肺炎）的各种肿瘤进行了体内电阻抗测量。基于这些阻抗测量结果和体内等效电路，我们计算了组织中的细胞外电阻（Re）、细胞内液电阻（Ri）和细胞膜电容（Cm），并对各种疾病的这些参数进行了比较。结果发现，乳腺癌组织中的Re和Ri显著高于良性肿瘤和正常乳腺组织，而乳腺癌组织中的Cm显著低于其他组织。另一方面，正常肺组织中的Re和Ri显著高于肺部肿块，而Cm显著低于肺部肿块。恶性肿瘤中的Re和Ri显著高于机化性肺炎，而Cm显著低于机化性肺炎。结果表明，这些参数（Re、Ri和Cm）在各种组织和肿瘤之间存在显著差异，提示其在肿瘤诊断中可能具有应用价值。
