Babu Anish, Ramesh Rajagopal
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Mar Drugs. 2017 Mar 27;15(4):96. doi: 10.3390/md15040096.
Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights the recent applications of chitosan and chitosan derivatives in cancer therapy.
壳聚糖是一种具有多种用途的生物源多糖。由于壳聚糖具有生物相容性和可生物降解性，它在生物医学应用中被广泛用于支架工程，作为吸收增强剂以及用于生物活性和可控药物释放。在癌症治疗中，壳聚糖有多种应用，如协助基因传递和化疗药物传递，以及作为疫苗的免疫佐剂。本综述重点介绍了壳聚糖及其衍生物在癌症治疗中的最新应用。
