Center of Excellence for Advanced Research in Fluid Flow (CARIFF), Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang, Gambang 26300, Kuantan, Malaysia.
Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh.
Curr Drug Deliv. 2019;16(4):272-294. doi: 10.2174/1567201816666190123121425.
Chitosan is a polycationic natural polymer which is abundant in nature. Chitosan has gained much attention as natural polymer in the biomedical field. The up to date drug delivery as well as the nanotechnology in controlled release of drugs from chitosan nanofibers are focused in this review. Electrospinning is one of the most established and widely used techniques for preparing nanofibers. This method is versatile and efficient for the production of continuous nanofibers. The chitosan-based nanofibers are emerging materials in the arena of biomaterials. Recent studies revealed that various drugs such as antibiotics, chemotherapeutic agents, proteins and anti-inflammatory analgesic drugs were successfully loaded onto electrospun nanofibers. Chitosan nanofibers have several outstanding properties for different significant pharmaceutical applications such as wound dressing, tissue engineering, enzyme immobilization, and drug delivery systems. This review highlights different issues of chitosan nanofibers in drug delivery applications, starting from the preparation of chitosan nanofibers, followed by giving an idea about the biocompatibility and degradation of chitosan nanofibers, then describing how to load the drug into the nanofibers. Finally, the major applications of chitosan nanofibers in drug delivery systems.
壳聚糖是一种天然存在的多阳离子聚合物，在生物医学领域作为天然聚合物受到了广泛关注。本文综述了壳聚糖纳米纤维中药物的最新控释和纳米技术的药物传递。静电纺丝是制备纳米纤维最成熟和广泛使用的技术之一。这种方法对于制备连续纳米纤维非常通用和有效。壳聚糖基纳米纤维是生物材料领域的新兴材料。最近的研究表明，各种药物，如抗生素、化疗药物、蛋白质和抗炎镇痛药，已成功负载到电纺纳米纤维上。壳聚糖纳米纤维具有多种优异的性质，可用于不同的重要药物应用，如伤口敷料、组织工程、酶固定化和药物传递系统。本文从壳聚糖纳米纤维的制备开始，综述了壳聚糖纳米纤维在药物传递应用中的不同问题，介绍了壳聚糖纳米纤维的生物相容性和降解性，然后描述了如何将药物载入纳米纤维。最后，介绍了壳聚糖纳米纤维在药物传递系统中的主要应用。
