Srinivasan Mathangi, Rajabi Mehdi, Mousa Shaker A
The Pharmaceutical Research Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA.
Nanomaterials (Basel). 2015 Oct 14;5(4):1690-1703. doi: 10.3390/nano5041690.
The field of nanotechnology has led to the development of many innovative strategies for effective detection and treatment of cancer, overcoming limitations associated with conventional cancer diagnosis and therapy. Multifunctional nanoparticle systems can integrate imaging, targeting and treatment moieties on the surface and in the core, resulting in targeted delivery of the imaging or treatment modalities, specifically to the tumor. Multifunctional nanoparticles also enable simultaneous delivery of multiple treatment agents, resulting in effective combinatorial therapeutic regimens against cancer. In this review, various multifunctional nanoparticle systems that feature a variety of targeting moieties for and/or cancer imaging and therapy are discussed.
纳米技术领域已催生了许多用于有效检测和治疗癌症的创新策略，克服了传统癌症诊断和治疗的局限性。多功能纳米粒子系统可以在表面和核心整合成像、靶向和治疗部分，从而实现成像或治疗方式的靶向递送，特别是递送至肿瘤部位。多功能纳米粒子还能够同时递送多种治疗药物，从而形成针对癌症的有效联合治疗方案。在本综述中，将讨论各种具有多种用于癌症成像和治疗的靶向部分的多功能纳米粒子系统。
