Howard Hughes Medical Institute, Chevy Chase, Maryland 20815.
Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520.
Cold Spring Harb Perspect Med. 2018 Feb 1;8(2):a025742. doi: 10.1101/cshperspect.a025742.
Over the past 40 years, remarkable advances have been made in our understanding of successful blood vessel regeneration, starting with the failures of early tissue-engineered vascular grafts designed using isolated components or molecules, such as collagen gels. The vascular tissue engineers are today better educated and have steered ongoing research developments toward clinical developments of more complete vascular grafts that replicate the multitude of specialized arterial aspects required for function.
在过去的 40 年中,我们对成功的血管再生的理解取得了显著的进展,这要从早期使用分离的成分或分子(如胶原蛋白凝胶)设计的组织工程血管移植物的失败开始。血管组织工程师们如今受到了更好的教育,并引导着正在进行的研究发展,朝着更完整的血管移植物的临床开发方向发展,这些移植物复制了功能所需的多种特殊动脉方面。