Lin Jin-Bo, Zhang Lei, Wu Dong-Wen, Xi Zhou-Huan, Wang Xue-Jun, Lin Yun-Shou, Fujiwara Wakana, Tian Jing-Ru, Wang Min, Peng Peng, Guo Ai, Yang Zhen, Luo Le, Jiang Ling-Ya, Li Qia-Qia, Zhang Xue-Ying, Zhang Yun-Feng, Xu Hou-Wei, Yang Bing, Li Xun-Lin, Lei Yi-Xiong
Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
World J Gastroenterol. 2017 Mar 14;23(10):1891-1898. doi: 10.3748/wjg.v23.i10.1891.
To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC).
From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's α coefficient, the Spearman correlation test and Wilcoxon rank sum test.
The EORTC QLQ-CR29 showed satisfactory reliability (α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (α = 0.608). The multitrait scaling analyses showed good convergent ( > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS ≤ 80; KPS > 80). Body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients.
The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.
评估欧洲癌症研究与治疗组织结直肠癌生活质量问卷29（EORTC QLQ-CR29）在中国结直肠癌（CRC）患者中的有效性和可靠性。
2014年3月至2015年1月，来自中国四家不同医院的356例CRC患者纳入本研究，所有患者自行填写EORTC QLQ-CR29和生活质量核心问卷（EORTC QLQ-C30）。基于卡诺夫斯基性能量表（KPS）对得分进行评估。通过克朗巴哈α系数、斯皮尔曼相关性检验和威尔科克森秩和检验对问卷的可靠性和有效性进行评估。
EORTC QLQ-CR29显示出令人满意的可靠性（α>0.7），尽管尿频、便血和黏液便维度的可靠性仅为中等（α=0.608）。多特质量表分析显示出良好的收敛效度（>0.4）和区分效度。不同KPS亚组（KPS≤80；KPS>80）中各项目存在显著差异。与其他患者相比，造口患者的身体形象和大多数单项维度存在统计学显著差异。
EORTC QLQ-CR29在中国CRC患者中具有较高的有效性和可靠性，因此可推荐作为评估这些患者生活质量的有价值工具。
