Centre Alexis Vautrin, Department of Medical Oncology, Nancy, France.
Health Qual Life Outcomes. 2011 Aug 22;9:70. doi: 10.1186/1477-7525-9-70.
The aim of this study was to compare the responsiveness of the European Organization for Research and Treatment (EORTC) quality of life questionnaires (QLQ-C30, QLQ-CR38) and the Functional Assessment of Cancer Therapy-colorectal version 4 questionnaire (FACT-C).
This prospective study included 127 patients with colorectal cancer: 71 undergoing chemotherapy and 56 radiation therapy. Responsiveness statistics included the Standardized Response Mean (SRM) and the Effect Size (ES). The patient's overall assessment of his/her change in state of health status was the reference criterion to evaluate the responsiveness of the QoL questionnaires.
34 patients perceived their health as stable and 17 as improved between the first and the fourth courses of chemotherapy. 21 patients perceived their health as stable and 22 as improved between before and the last week of radiotherapy.The responsiveness of the 3 questionnaires differed according to treatments. The EORTC QLQ-C30 questionnaire was more responsive in patients receiving chemotherapy, particulary functional scales (SRM > 0.55). The QLQ-CR38 and the FACT-C questionnaires provided little clinically relevant information during chemotherapy or radiotherapy.
The EORTC QLQ-C30 questionnaire appears to be more responsive in patients receiving chemotherapy.
本研究旨在比较欧洲癌症研究与治疗组织（EORTC）生活质量问卷（QLQ-C30、QLQ-CR38）和癌症治疗功能评估-结肠直肠版 4 问卷（FACT-C）的反应性。
本前瞻性研究纳入了 127 例结直肠癌患者：71 例接受化疗，56 例接受放疗。反应性统计包括标准化反应均值（SRM）和效应量（ES）。患者对其健康状况变化的整体评估是评估生活质量问卷反应性的参考标准。
34 例患者认为他们的健康状况在第一至第四疗程化疗期间保持稳定，17 例患者认为他们的健康状况有所改善。21 例患者认为他们的健康状况在放疗前和最后一周保持稳定，22 例患者认为他们的健康状况有所改善。3 种问卷的反应性因治疗而异。EORTC QLQ-C30 问卷在接受化疗的患者中更具反应性，特别是功能量表（SRM > 0.55）。QLQ-CR38 和 FACT-C 问卷在化疗或放疗期间提供的临床相关信息较少。
EORTC QLQ-C30 问卷在接受化疗的患者中似乎更具反应性。
