果糖：对心脏肾脏风险因素及氧化还原状态的毒性作用。
Fructose: Toxic effect on cardiorenal risk factors and redox state.
作者信息
Francisqueti Fabiane V, Santos Klinsmann C, Ferron Artur Jt, Lo Angelo Tc, Minatel Igor O, Campos Dijon Hs, Ferreira Ana Lucia A, Corrêa Camila R
机构信息
State University (Unesp), Medical School, Botucatu.
State University (Unesp), Medical School, Botucatu; State University (Unesp), Institute of Biosciences, Botucatu.
出版信息
SAGE Open Med. 2016 Dec 14;4:2050312116684294. doi: 10.1177/2050312116684294. eCollection 2016.
AIM
To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal.
METHODS
Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed.
RESULTS
Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group.
CONCLUSION
Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.
目的
研究摄入果糖对心脏和肾脏抗氧化能力、心血管疾病危险因素的影响，以及停止摄入果糖后这些变量的评估情况。
方法
将36只雄性Wistar大鼠分为对照组（n = 12）：标准饲料+水，或F组：标准饲料+含30%果糖的饮用水，持续15周。之后，将F组再分为两组，一组继续接受标准饲料+含30%果糖的饮用水（n = 目标：研究摄入果糖对心脏和肾脏抗氧化能力、心血管疾病危险因素的影响，以及停止摄入果糖后这些变量的评估情况。
方法
将36只雄性Wistar大鼠分为对照组（n = 12）：标准饲料+水，或F组：标准饲料+含30%果糖的饮用水，持续15周。之后，将F组再分为两组，一组继续接受标准饲料+含30%果糖的饮用水（n = 12），另一组接受标准饲料+水（Ex组，n = 12），持续9周。分析水、饲料和热量日记摄入量、最终体重、肥胖指数、血浆葡萄糖和三酰甘油、收缩压以及心脏和肾脏亲水性抗氧化能力。
结果
与F组相比，对照组和Ex组的饲料和水消耗量较少。对照组的热量摄入量较高。最终体重和肥胖指数没有差异。F组的收缩压以及心脏和肾脏亲水性抗氧化能力最差。
结论
长期接触果糖会诱导氧化应激、收缩压升高和三酰甘油增加。停止摄入果糖后，Ex组的这些变量有所改善，表明大量且长期摄入果糖具有毒性作用。 12），另一组接受标准饲料+水（Ex组，n = 12），持续9周。分析水、饲料和热量日记摄入量、最终体重、肥胖指数、血浆葡萄糖和三酰甘油、收缩压以及心脏和肾脏亲水性抗氧化能力。
结果
与F组相比，对照组和Ex组的饲料和水消耗量较少。对照组的热量摄入量较高。最终体重和肥胖指数没有差异。F组的收缩压以及心脏和肾脏亲水性抗氧化能力最差。
结论
长期接触果糖会诱导氧化应激、收缩压升高和三酰甘油增加。停止摄入果糖后，Ex组的这些变量有所改善，表明大量且长期摄入果糖具有毒性作用。
Zotero 插件