Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Street, Ivano-Frankivsk 76025, Ukraine.
Biomed Res Int. 2013;2013:343914. doi: 10.1155/2013/343914. Epub 2013 Jul 24.
There is compelling evidence that long-term intake of excessive fructose can have deleterious side effects in different experimental models. However, the role of fructose in vivo remains controversial, since acute temporary application of fructose is found to protect yeast as well as animal tissues against exogenous oxidative stress. This review suggests the involvement of reactive carbonyl and oxygen species in both the cytotoxic and defensive effects of fructose. Potential mechanisms of the generation of reactive species by fructose in the nonenzymatic reactions, their implication in the detrimental and protective effects of fructose are discussed.
有确凿的证据表明，长期摄入过量的果糖会对不同的实验模型产生有害的副作用。然而，果糖在体内的作用仍然存在争议，因为急性短暂应用果糖被发现可以保护酵母以及动物组织免受外源性氧化应激。这篇综述表明，活性羰基和氧自由基参与了果糖的细胞毒性和防御作用。本文讨论了非酶反应中果糖产生活性物质的潜在机制，以及它们在果糖的有害和保护作用中的意义。
