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[物质名称]提取物对胃癌细胞的抗癌和抗血管生成特性 。（注：原文中“of on”表述有误，推测是“of [物质名称] on”，这里[物质名称]未给出，所以翻译时做了模糊处理）

Anti-carcinogenic and anti-angiogenic properties of the extracts of on gastric cancer cells.

作者信息

Rahamooz Haghighi Samaneh, Asadi Malek Hossein, Akrami Hassan, Baghizadeh Amin

机构信息

Department of Plant Breeding, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran.

Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

出版信息

Avicenna J Phytomed. 2017 Mar-Apr;7(2):145-156.

PMID:28348970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5355820/
Abstract

OBJECTIVE

() has been used as a medicinal plant in Asia for its effects on digestive system for the last 2000 years. To investigate the anti-cancer activity of rhizome of , the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (AGS).

MATERIALS AND METHODS

The viability of cells which were treated with the extracts and the essential oil was assessed by MTT assay. To evaluate the anti-angiogenic property of the extracts, tube formation assay was done. Cell cycle distribution and the expression of Oct4 and Nucleostemin, after treatments, were checked by flowcytometry and quantitative RT-PCR, respectively. Furthermore, analysis of essential oil from was done by GC-MS.

RESULTS

Our results showed that the growth of AGS cells was inhibited by the extracts and essential oil and the extracts inhibited the angiogenesis in HUVEC cells. Our data revealed that the extracts and essential oil of caused G1 arrest in AGS cells and downregulation of Oct4 and NS after treatment. By GC-MS analysis, we found new compounds such as epiprezizaene, valencene and isocyclocitral in essential oil of

CONCLUSION

All together, our results showed that the extracts of have anti-proliferative and anti-angiogenic effects on cancer cells.

摘要

目的

在过去2000年里，（）作为一种药用植物因其对消化系统的作用而在亚洲被使用。为了研究（）根茎的抗癌活性，制备了根茎的乙醇提取物、甲醇提取物和精油，并评估了它们对人胃癌细胞系（AGS）的影响。

材料与方法

用MTT法评估用提取物和精油处理后的细胞活力。为了评估提取物的抗血管生成特性，进行了管形成试验。处理后，分别通过流式细胞术和定量RT-PCR检查细胞周期分布以及Oct4和核干细胞素的表达。此外，对（）的精油进行了GC-MS分析。

结果

我们的结果表明，提取物和精油抑制了AGS细胞的生长，且提取物抑制了人脐静脉内皮细胞（HUVEC）的血管生成。我们的数据显示，（）的提取物和精油导致AGS细胞G1期阻滞，并在处理后下调Oct4和核干细胞素。通过GC-MS分析，我们在（）的精油中发现了新的化合物，如表普雷齐烷、瓦伦烯和异环柠檬醛。

结论

总之，我们的结果表明，（）的提取物对癌细胞具有抗增殖和抗血管生成作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f14/5355820/5f121ffa6cb4/AJP-7-145-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f14/5355820/5f121ffa6cb4/AJP-7-145-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f14/5355820/5f121ffa6cb4/AJP-7-145-g004.jpg

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