Sharma Vineet, Sharma Rohit, Gautam DevNath Singh, Kuca Kamil, Nepovimova Eugenie, Martins Natália
Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi 221005, Uttar Pradesh, India.
Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech Republic.
J Clin Med. 2020 Apr 19;9(4):1176. doi: 10.3390/jcm9041176.
Vacha ( Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of to improve neurological and metabolic disorders.
瓦查（林奈（天南星科））是一种传统的印度药草，用于治疗多种健康疾病，包括神经、胃肠、呼吸、代谢、肾脏和肝脏疾病。本文的目的是提供一份关于其民族药用、植物化学和药物治疗潜力的全面最新报告，同时确定进一步研究的潜在领域。迄今为止，已从这种药草中分离并鉴定出145种成分，包括苯丙素类、倍半萜类和单萜类。有力证据表明其各种提取物和活性成分在几种代谢和神经疾病中具有生物活性，如抗惊厥、抗抑郁、抗高血压、抗炎、免疫调节、神经保护、心脏保护和抗肥胖作用。目前广泛的文献调查有望深入了解几种信号通路和氧化机制的参与情况，这些机制可以减轻氧化应激，以及由其活性生物分子调节的其他间接机制，以改善神经和代谢疾病。
