Morales-Lázaro Sara L, Lemus Luis, Rosenbaum Tamara
Department of Cognitive Neuroscience, Instituto de Fisiología Celular, Circuito exterior s/n, Universidad Nacional Autónoma de México , Coyoacan, México City, Mexico.
Temperature (Austin). 2016 Nov 1;4(1):24-40. doi: 10.1080/23328940.2016.1254136. eCollection 2017.
The family of Transient Receptor Potential (TRP) ion channels is constituted by 7 subfamilies among which are those that respond to temperature, the thermoTRPs. These channels are versatile molecules of a polymodal nature that have been shown to be modulated in various fashions by molecules of a lipidic nature. Some of these molecules interact directly with the channels on specific regions of their structures and some of these promote changes in membrane fluidity or modify their gating properties in response to their agonists. Here, we have discussed how some of these lipids regulate the activity of thermoTRPs and included some of the available evidence for the molecular mechanisms underlying their effects on these channels.
瞬时受体电位（TRP）离子通道家族由7个亚家族组成，其中包括对温度作出反应的热TRP通道。这些通道是多模态性质的多功能分子，已被证明会受到脂质分子以各种方式的调节。其中一些分子在其结构的特定区域与通道直接相互作用，还有一些分子会促进膜流动性的变化或响应其激动剂而改变其门控特性。在这里，我们讨论了其中一些脂质如何调节热TRP通道的活性，并纳入了一些关于其对这些通道产生影响的分子机制的现有证据。
