Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.
Acta Derm Venereol. 2018 Jun 8;98(6):546-550. doi: 10.2340/00015555-2912.
It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan-Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with duration of cutaneous symptoms (p = 0.0001). Psoriasis diagnosed before age 20 or 30 years, respectively, suggested a lower risk of PsA than psoriasis diagnosed after age 50 years, yet age at first cutaneous symptoms did not predict development of PsA. No clear association with disease severity was found. PsA incidence appeared stable with longer duration of psoriasis, but further data are needed to firmly establish the relationship with age of psoriasis onset.
目前尚不清楚银屑病是否是一种需要早期积极干预的进行性疾病。本项基于人群的研究确定了患有银屑病和银屑病关节炎（PsA）的患者。使用生存分析和 Kaplan-Meier 生命表技术。该研究包括 10011 例银屑病患者（重度 n=4618），其中 1269 例患者同时患有 PsA。随着皮肤症状持续时间的延长，PsA 的发病率增加（p=0.0001）。分别在 20 岁或 30 岁之前或之前诊断出的银屑病，表明发生 PsA 的风险低于 50 岁以后诊断出的银屑病，然而首次出现皮肤症状的年龄并不能预测 PsA 的发展。未发现与疾病严重程度有明确关联。随着银屑病持续时间的延长，PsA 的发病率似乎保持稳定，但需要进一步的数据来确定与银屑病发病年龄的关系。
