Hay Ashley, Migliacci Jocelyn, Karassawa Zanoni Daniella, Boyle Jay O, Singh Bhuvanesh, Wong Richard J, Patel Snehal G, Ganly Ian
Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Oral Oncol. 2017 Apr;67:160-166. doi: 10.1016/j.oraloncology.2017.02.022. Epub 2017 Feb 28.
To report the complications occurring following TORS and to identify the factors predictive of complications.
Following IRB approval a retrospective analysis of all TORS operations at our institution was performed. Postoperative complications within 45days were collected and graded with the Clavien-Dindo system. Complications were categorized into groups: all complications, not related to TORS and TORS related. Unadjusted odds ratios were calculated to test association between patients with and without a complication.
122 TORS operations were carried out between June 2010 and August 2015. 77% were male, with a median age of 57. There were 92 primary tumor resections, 10second head and neck primary resections, 13 salvage procedures and 7 other indications. Surgical resection involved 1, 2 or >3 sub-sites in 36%, 28% and 36% patients, respectively. Overall, there were 107 complications (66 TORS related, 41 non-TORS related) that occurred in 57 patients (47%). A major complication occurred in 23 patients (18%). 19 patients had a TORS related major complication and 6 patients experienced a non-TORS related major complication. There was a temporal trend in TORS related major complication rate decreasing from 33% in 2010 to 10% in 2015. Statistical analysis showed that the odds of having any complication were 3 times greater in patients over 60years old (p=0.017), and 2.5 times greater when there were more than 2 subsites resected (p=0.022).
Age over 60years and a larger extent of resection were the significant factors predictive of major complications.
报告经口机器人手术(TORS)后发生的并发症,并确定并发症的预测因素。
经机构审查委员会批准后,对我们机构所有的TORS手术进行回顾性分析。收集45天内的术后并发症,并根据Clavien-Dindo系统进行分级。并发症分为几组:所有并发症、与TORS无关的并发症和与TORS相关的并发症。计算未调整的优势比,以检验有并发症和无并发症患者之间的关联。
2010年6月至2015年8月期间共进行了122例TORS手术。77%为男性,中位年龄为57岁。有92例原发性肿瘤切除术、10例头颈部原发性二次切除术、13例挽救性手术和7例其他适应证。手术切除分别涉及1个、2个或超过3个亚部位的患者比例为36%、28%和36%。总体而言,57例患者(47%)发生了107例并发症(66例与TORS相关,41例与TORS无关)。23例患者(18%)发生了严重并发症。19例患者发生了与TORS相关的严重并发症,6例患者发生了与TORS无关的严重并发症。与TORS相关的严重并发症发生率呈时间趋势,从2010年的33%降至2015年的10%。统计分析表明,60岁以上患者发生任何并发症的几率高3倍(p = 0.017),切除超过2个亚部位时发生并发症的几率高2.5倍(p = 0.022)。
60岁以上和更大范围的切除是严重并发症的重要预测因素。