The Helmholtz Sino-German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, PR China.
Diagn Pathol. 2012 Sep 19;7:123. doi: 10.1186/1746-1596-7-123.
Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported in the English literature, one of which involved multiple brain metastases. Here, we report two cases of primary pulmonary malignant melanoma. The first case, which occurred in a 52-year-old Chinese female patient who died 4 months after the initial diagnosis, involved rapid intrapulmonary and intracranial metastases. The second patient, a 65-year-old female, underwent surgical excision, and clinical examination, histopathological characteristics, and immunohistochemical features supported the diagnosis of pulmonary malignant melanoma. No evidence for recurrence and/or metastasis has been found more than one year after the initial surgery. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin must be excluded by detailed examination. Moreover, the tumor should be removed surgically whether it occurs as a single lesion or multiple lesions.
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呼吸道恶性黑色素瘤几乎均为转移性起源，而原发性肿瘤非常罕见。据我们所知，英文文献中约有 30 例报道，其中 1 例涉及多个脑转移。在此，我们报告 2 例原发性肺恶性黑色素瘤。第 1 例为 52 岁中国女性患者，初诊后 4 个月死亡，其肺部和颅内转移迅速。第 2 例为 65 岁女性，接受了手术切除，临床检查、组织病理学特征和免疫组织化学特征均支持肺恶性黑色素瘤的诊断。初次手术后一年多未发现复发和/或转移的证据。为了确诊原发性肺恶性黑色素瘤，必须通过详细检查排除任何肺外起源。此外，无论肿瘤是单发还是多发，都应通过手术切除。
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