Song Peige, Chang Xinlei, Wang Manli, An Lin
Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
PLoS One. 2017 Mar 29;12(3):e0174587. doi: 10.1371/journal.pone.0174587. eCollection 2017.
Pterygium is a common chronic ophthalmic condition, which may result in significant visual morbidity or lead to blindness in extreme cases. The prevalence of pterygium in China has not been reported at the sub-national level.
In this study, we conducted a systematic review and meta-analysis to estimate the prevalence of pterygium in China. China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedicine Literature Database (CBM-SinoMed), PubMed, Embase and Medline were searched before September 2016. We performed a multilevel mixed-effect meta-regression based on the included studies, our results showed that age, gender and latitude were significantly associated with pterygium prevalence. Based on the final model, the age and gender-specific prevalence of pterygium in 31 Chinese provinces (except Hongkong, Macau and Taiwan) and the whole country was generated.
In 2010, the overall prevalence of pterygium in Chinese people aged 15-84 years was 9.84% (95% CI: 6.72-14.14), and the number of pterygium cases in China was 108.65 million (95% CI: 74.23-156.13).
In conclusion, the prevalence of pterygium in Chinese population in 2010 was estimated at both the national and provincial levels. The higher burden of pterygium across the country calls for efforts to advocate public health education encouraging people to take appropriate protective measures.
翼状胬肉是一种常见的慢性眼科疾病，在极端情况下可能导致严重的视力损害甚至失明。中国各地区翼状胬肉的患病率尚未见报道。
在本研究中，我们进行了一项系统评价和荟萃分析，以估计中国翼状胬肉的患病率。检索了中国知网（CNKI）、万方、中国生物医学文献数据库（CBM-SinoMed）、PubMed、Embase和Medline等数据库，检索时间截至2016年9月。我们基于纳入的研究进行了多层次混合效应荟萃回归分析，结果显示年龄、性别和纬度与翼状胬肉患病率显著相关。根据最终模型，得出了中国31个省（不包括香港、澳门和台湾）以及全国按年龄和性别划分的翼状胬肉患病率。
2010年，15 - 84岁中国人翼状胬肉的总体患病率为9.84%（95%置信区间：6.72 - 14.14），中国翼状胬肉患者数量为1.0865亿（95%置信区间：7423万 - 1.5613亿）。
总之，本研究估计了2010年中国全国及各省级层面翼状胬肉的患病率。全国范围内翼状胬肉负担较重，需要努力倡导公共健康教育，鼓励人们采取适当的防护措施。
