Poyrazoglu Omer Bilgehan, Dulger Ahmet Cumhur, Gultepe Bilge Sumbul
Lokman Hekim Hospital, General Surgery, Van, Turkey.
Yuzuncu Yil University, School of Medicine, Department of Gastroenterology, Van, Turkey.
Clinics (Sao Paulo). 2017 Mar;72(3):150-153. doi: 10.6061/clinics/2017(03)04.
: Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy.
: The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively.
: The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively).
: These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy.
食管鳞状细胞癌是发展中国家最常见的食管疾病之一，但食管鳞状细胞癌与幽门螺杆菌感染之间的关系仍是一个被忽视的话题。本研究的主要目的是确定幽门螺杆菌感染与食管鳞状细胞癌之间的关联。第二个目的是确定食管切除术后幽门螺杆菌感染的发生率及相关因素。
通过检测95例食管鳞状细胞癌患者（66例女性；39例行食管切除术）胃活检材料在含尿素培养基中的尿素酶活性及氢离子检测试剂，并将结果与健康人群进行比较来鉴定微生物。分别用卡方检验和t检验评估分类因素和连续因素患者特征的差异。
食管鳞状细胞癌患者的幽门螺杆菌感染率显著低于健康人群（p<0.001）。相比之下，未行食管切除术的患者和行食管切除术的患者在幽门螺杆菌感染方面无显著差异（p>0.005）。食管鳞状细胞癌患者中，白细胞增多症、低球蛋白血症与幽门螺杆菌感染之间存在显著关联（分别为p=0.023和p=0.045）。
这些结果表明幽门螺杆菌不是食管鳞状细胞癌患者的病因。我们发现食管鳞状细胞癌与幽门螺杆菌感染之间存在统计学上显著的负相关。这些发现可能为食管鳞状细胞癌的治疗指引新策略。
