幽门螺杆菌血清阳性与消化道癌症的关系。
Association between Helicobacter pylori seropositivity and digestive tract cancers.
机构信息
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China.
出版信息
World J Gastroenterol. 2009 Nov 21;15(43):5465-71. doi: 10.3748/wjg.15.5465.
AIM
To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers.
METHODS
In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital- and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG.
RESULTS
Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon.
CONCLUSION
Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.
目的
探讨幽门螺杆菌（H pylori）感染对消化道癌症风险的作用。
方法
共招募了 199 例口腔鳞状细胞癌（SCC）、317 例食管 SCC、196 例胃贲门和非贲门腺癌以及 240 例结肠腺癌患者进行 H pylori 感染的血清学检测。采用酶联免疫吸附试验法检测 H pylori IgG，以医院和社区为基础设立两组对照。
结果
与三组对照组相比，H pylori 感染的存在与食管 SCC 呈显著负相关（调整后的比值比[OR]：0.315-0.472，均 P 值<0.05），但与胃腺癌（贲门和非贲门）呈显著正相关（OR：1.636-3.060，均 P 值<0.05）。在口腔和结肠癌症中未发现类似结果。
结论
我们的研究结果支持 H pylori 血清阳性与食管 SCC 风险呈负相关，但增加胃贲门腺癌风险的发现。
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