合成生物学：基于生物物理原理构建生命系统
Synthetic Biology: Engineering Living Systems from Biophysical Principles.
作者信息
Bartley Bryan A, Kim Kyung, Medley J Kyle, Sauro Herbert M
机构信息
Department of Bioengineering, University of Washington, Seattle, Washington.
Department of Bioengineering, University of Washington, Seattle, Washington.
出版信息
Biophys J. 2017 Mar 28;112(6):1050-1058. doi: 10.1016/j.bpj.2017.02.013.
Synthetic biology was founded as a biophysical discipline that sought explanations for the origins of life from chemical and physical first principles. Modern synthetic biology has been reinvented as an engineering discipline to design new organisms as well as to better understand fundamental biological mechanisms. However, success is still largely limited to the laboratory and transformative applications of synthetic biology are still in their infancy. Here, we review six principles of living systems and how they compare and contrast with engineered systems. We cite specific examples from the synthetic biology literature that illustrate these principles and speculate on their implications for further study. To fully realize the promise of synthetic biology, we must be aware of life's unique properties.
合成生物学作为一门生物物理学科而创立，旨在从化学和物理的第一原理探寻生命起源的解释。现代合成生物学已被重塑为一门工程学科，用于设计新的生物体以及更好地理解基本生物学机制。然而，成功仍在很大程度上限于实验室，合成生物学的变革性应用仍处于起步阶段。在此，我们回顾生命系统的六个原理，以及它们与工程系统的比较和对比。我们引用合成生物学文献中的具体例子来说明这些原理，并推测它们对进一步研究的意义。为了充分实现合成生物学的前景，我们必须了解生命的独特属性。
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