Atar Arda, Kural Alev, Yenice Gurkan, Comez Ilker, Tugcu Volkan
Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Kaohsiung J Med Sci. 2017 Apr;33(4):195-200. doi: 10.1016/j.kjms.2017.01.007. Epub 2017 Feb 28.
Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Plasma PTX3 and IL-6 concentrations were evaluated in 40 patients in the acute phase of PD and 40 healthy controls by enzyme-linked immunosorbent assay. Serum concentrations of both PTX3 and IL-6 were significantly higher in the PD patients than in the control group (p=0.001 and p=0.001, respectively). There was a significant correlation between concentration of PTX3 and painful erections. IL-6 concentrations were significantly higher in patients with erectile dysfunction. IL-6 and PTX3 levels showed no correlation with age, serum C-reactive protein, degree of curvature, and disease duration. IL-6 trans-signaling and PTX3 amplification at the site of inflammation could have a role in pathophysiological mechanisms of PD. Biological drugs may be used for treatment during the acute phase of the disease based on this mechanism.
炎症在佩罗尼氏病（PD）的发病机制中起作用。本研究的目的是评估血清五聚体蛋白3（PTX3）和白细胞介素-6（IL-6）浓度在PD中的相关性。该研究纳入了40例急性期PD患者和40名健康对照者。通过酶联免疫吸附测定法评估了40例急性期PD患者和40名健康对照者的血浆PTX3和IL-6浓度。PD患者的PTX3和IL-6血清浓度均显著高于对照组（分别为p = 0.001和p = 0.001）。PTX3浓度与疼痛性勃起之间存在显著相关性。勃起功能障碍患者的IL-6浓度显著更高。IL-6和PTX3水平与年龄、血清C反应蛋白、弯曲程度和病程均无相关性。炎症部位的IL-6转信号传导和PTX3扩增可能在PD的病理生理机制中起作用。基于这一机制，生物药物可在疾病急性期用于治疗。
