Fleming J O, el Zaatari F A, Gilmore W, Berne J D, Burks J S, Stohlman S A, Tourtellotte W W, Weiner L P
Department of Neurology, School of Medicine, University of Southern California, Los Angeles 90033.
Arch Neurol. 1988 Jun;45(6):629-33. doi: 10.1001/archneur.1988.00520300047017.
Many studies have either supported or discounted the role of coronaviruses as etiologic agents in multiple sclerosis (MS). Two new approaches were applied to investigate this controversy. First, monoclonal antibodies specific for either murine coronaviruses (mouse hepatitis viruses) or human coronaviruses were used to characterize the antigenic features of MS-derived coronaviruses SK and SD. Both isolates were found to have a mouse hepatitis virus-type profile. Second, serum and cerebrospinal fluid antibodies to different coronaviruses, including SD, were measured in MS and control groups. No significant difference in antibody level to coronaviruses was found between MS and control samples. The results of these antigenic studies do not support a specific association between MS and coronaviruses.
许多研究要么支持冠状病毒作为多发性硬化症（MS）病原体的作用，要么对其作用予以否定。为研究这一争议，采用了两种新方法。首先，使用针对鼠冠状病毒（小鼠肝炎病毒）或人冠状病毒的单克隆抗体来表征源自MS的冠状病毒SK和SD的抗原特征。发现这两种分离株均具有小鼠肝炎病毒类型的特征。其次，在MS组和对照组中检测了针对包括SD在内的不同冠状病毒的血清和脑脊液抗体。MS样本和对照样本之间在冠状病毒抗体水平上未发现显著差异。这些抗原研究的结果不支持MS与冠状病毒之间存在特定关联。
