Khateb Mohamed, Bosak Noam, Muqary Maryam
Department of Neurology, Rambam Health Care Campus, Haifa, Israel.
Department of Psychiatry, Rambam Health Care Campus, Haifa, Israel.
Front Neurol. 2020 Jun 23;11:715. doi: 10.3389/fneur.2020.00715. eCollection 2020.
SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种高致病性冠状病毒，已在全球范围内引发持续的大流行。该病毒于2019年12月在中国武汉出现，并迅速在全球传播。由SARS-CoV-2引起的2019冠状病毒病（COVID-19）已导致大量发病和死亡。SARS-CoV-2感染最突出的症状是呼吸道症状。然而，越来越多的证据表明中枢神经系统（CNS）也受到影响。这包括头痛、嗅觉丧失、脑膜脑炎、急性缺血性中风，以及几种可能的感染后/感染旁综合征和无法用呼吸道病因解释的精神状态改变。有趣的是，先前在动物模型中的研究强调了冠状病毒的嗜神经性；因此，COVID-19的这些中枢神经系统表现并不令人惊讶。本综述简要浏览了有关中枢神经系统一般在冠状病毒感染中的参与情况的文献，特别是关于最近的SARS-CoV-2的文献。
