Stålenheim E G, von Knorring L, Wide L
Department of Forensic Psychiatry, University Hospital, Uppsala University, Sweden.
Biol Psychiatry. 1998 May 15;43(10):755-61. doi: 10.1016/s0006-3223(97)00302-8.
In a Swedish study, delinquent boys had high serum levels of triiodothyronine (T3). Furthermore, former delinquents, followed up after about 30 years, had T3 levels significantly related to repeated criminality. The aim of the present study was to shed further light on the relationship between the thyroid hormones and specific behaviors and personality characteristics.
Serum levels of T3 and free thyroxine (FT4) were measured in 61 nonpsychotic male subjects at forensic psychiatric examinations and 66 normal controls. Psychopathy was determined by means of the Psychopathy Checklist-Revised (PCL-R) and DSM-III-R, DSM-IV, and ICD-10 diagnoses.
The study population had high T3 and low FT4 values. Elevated T3 levels were related to type II alcoholism, Cluster B personality disorders, psychopathy as measured by the PCL-R, criminality, a diagnosis of a DSM-IV antisocial disorder, and an ICD-10 dissocial disorder. Serum levels of FT4 were negatively related to the same disorders and personality traits.
The results indicate an intimate relationship between T3 and FT4, and abuse and antisocial behavior. They emphasize the importance of further studies on T3 as a biological marker for abuse, social deviance, and repeated violent behavior.
在一项瑞典的研究中，违法犯罪的男孩血清三碘甲状腺原氨酸（T3）水平较高。此外，约30年后接受随访的有过违法犯罪经历者，其T3水平与再次犯罪显著相关。本研究的目的是进一步阐明甲状腺激素与特定行为及人格特征之间的关系。
在法医精神病学检查中，对61名非精神病男性受试者和66名正常对照者测定血清T3和游离甲状腺素（FT4）水平。通过《修订版精神病态量表》（PCL-R）以及DSM-III-R、DSM-IV和ICD-10诊断来确定精神病态。
研究人群的T3值较高而FT4值较低。T3水平升高与II型酒精中毒、B类人格障碍、PCL-R所测定的精神病态、犯罪行为、DSM-IV反社会障碍诊断以及ICD-10反社会型障碍相关。FT4血清水平与相同的障碍及人格特质呈负相关。
结果表明T3与FT4、滥用及反社会行为之间存在密切关系。它们强调了进一步研究将T3作为滥用、社会偏差及反复暴力行为生物学标志物的重要性。
