Martel Sylvain
NanoRobotics Laboratory, Department of Computer & Software Engineering, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC, Canada.
Ther Deliv. 2017 Mar;8(5):301-312. doi: 10.4155/tde-2016-0088.
Paul Ehrlich's 'magic bullet' concept has stimulated research for therapeutic agents with the capability to go straight to their intended targets. The 'magic bullet' concept is still considered the ultimate approach to maximize the therapeutic effects of a given therapeutic agent without affecting nontargeted tissues. But so far, there has never been a therapeutic agent or a delivery system that goes straight to the target in the body, and no approach has provided anything better than just a few percents of the total administered dose reaching the intended target sites. But engineering principles can transform systematically circulating vectors that so far were based primarily on physical characteristics and biochemical principles alone, as smart therapeutic agents with the required propulsion-navigation-homing capabilities to enable them to go straight to their intended targets.
保罗·埃尔利希的“神奇子弹”概念激发了对具有直接靶向目标能力的治疗药物的研究。“神奇子弹”概念至今仍被视为在不影响非靶向组织的情况下最大化给定治疗药物治疗效果的终极方法。但到目前为止，还没有一种治疗药物或递送系统能直接到达体内的目标，也没有任何方法能使到达预期靶点的给药总量超过百分之几。但是工程原理可以将迄今为止主要仅基于物理特性和生化原理的系统性循环载体转变为具有所需推进 - 导航 - 归巢能力的智能治疗药物，使其能够直接到达预期靶点。
